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A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.
Pan S, Mi Y, Pally C, Beerli C, Chen A, Guerini D, Hinterding K, Nuesslein-Hildesheim B, Tuntland T, Lefebvre S, Liu Y, Gao W, Chu A, Brinkmann V, Bruns C, Streiff M, Cannet C, Cooke N, Gray N. Pan S, et al. Among authors: beerli c. Chem Biol. 2006 Nov;13(11):1227-34. doi: 10.1016/j.chembiol.2006.09.017. Chem Biol. 2006. PMID: 17114004
Orally bioavailable competitive CCR5 antagonists.
Thoma G, Nuninger F, Schaefer M, Akyel KG, Albert R, Beerli C, Bruns C, Francotte E, Luyten M, MacKenzie D, Oberer L, Streiff MB, Wagner T, Walter H, Weckbecker G, Zerwes HG. Thoma G, et al. Among authors: beerli c. J Med Chem. 2004 Apr 8;47(8):1939-55. doi: 10.1021/jm031046g. J Med Chem. 2004. PMID: 15055994
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: beerli c. J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b. J Med Chem. 2009. PMID: 19827831
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Weckbecker G, Pally C, Beerli C, Burkhart C, Wieczorek G, Metzler B, Morris RE, Wagner J, Bruns C. Weckbecker G, et al. Among authors: beerli c. Transpl Int. 2010 May 1;23(5):543-52. doi: 10.1111/j.1432-2277.2009.01015.x. Epub 2009 Dec 9. Transpl Int. 2010. PMID: 20003043 Free article.
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Wagner J, von Matt P, Faller B, Cooke NG, Albert R, Sedrani R, Wiegand H, Jean C, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: beerli c. J Med Chem. 2011 Sep 8;54(17):6028-39. doi: 10.1021/jm200469u. Epub 2011 Aug 8. J Med Chem. 2011. PMID: 21797275
40 results