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The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis.
Radstake TR, Franke B, Wenink MH, Nabbe KC, Coenen MJ, Welsing P, Bonvini E, Koenig S, van den Berg WB, Barrera P, van Riel PL. Radstake TR, et al. Among authors: wenink mh. Arthritis Rheum. 2006 Dec;54(12):3828-37. doi: 10.1002/art.22275. Arthritis Rheum. 2006. PMID: 17133580 Free article.
Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences.
Radstake TR, Nabbe KC, Wenink MH, Roelofs MF, Oosterlaar A, van Lieshout AW, Barrera P, van Lent PL, van den Berg WB. Radstake TR, et al. Among authors: wenink mh. Ann Rheum Dis. 2005 Dec;64(12):1737-43. doi: 10.1136/ard.2004.034405. Epub 2005 May 5. Ann Rheum Dis. 2005. PMID: 15878907 Free PMC article.
Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA).
Roelofs MF, Wenink MH, Brentano F, Abdollahi-Roodsaz S, Oppers-Walgreen B, Barrera P, van Riel PL, Joosten LA, Kyburz D, van den Berg WB, Radstake TR. Roelofs MF, et al. Among authors: wenink mh. Ann Rheum Dis. 2009 Sep;68(9):1486-93. doi: 10.1136/ard.2007.086421. Epub 2008 Sep 2. Ann Rheum Dis. 2009. PMID: 18765427 Free article.
The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Wenink MH, Santegoets KC, Roelofs MF, Huijbens R, Koenen HJ, van Beek R, Joosten I, Meyer-Wentrup F, Mathsson L, Ronnelid J, Adema GJ, Bonvini E, Koenig S, van den Berg WB, van Riel PL, Radstake TR. Wenink MH, et al. J Immunol. 2009 Oct 1;183(7):4509-20. doi: 10.4049/jimmunol.0900153. Epub 2009 Sep 4. J Immunol. 2009. PMID: 19734236
38 results