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Preparing the "soil": the premetastatic niche.
Kaplan RN, Rafii S, Lyden D. Kaplan RN, et al. Cancer Res. 2006 Dec 1;66(23):11089-93. doi: 10.1158/0008-5472.CAN-06-2407. Cancer Res. 2006. PMID: 17145848 Free PMC article. Review.
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.
Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D. Kaplan RN, et al. Nature. 2005 Dec 8;438(7069):820-7. doi: 10.1038/nature04186. Nature. 2005. PMID: 16341007 Free PMC article.
Niche-to-niche migration of bone-marrow-derived cells.
Kaplan RN, Psaila B, Lyden D. Kaplan RN, et al. Trends Mol Med. 2007 Feb;13(2):72-81. doi: 10.1016/j.molmed.2006.12.003. Epub 2007 Jan 2. Trends Mol Med. 2007. PMID: 17197241 Review.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. Peinado H, et al. Among authors: kaplan rn. Nat Med. 2012 Jun;18(6):883-91. doi: 10.1038/nm.2753. Nat Med. 2012. PMID: 22635005 Free PMC article.
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.
Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, Cotari J, Alpaugh ML, de Stanchina E, Manova K, Li M, Bonafe M, Ceccarelli C, Taffurelli M, Santini D, Altan-Bonnet G, Kaplan R, Norton L, Nishimoto N, Huszar D, Lyden D, Bromberg J. Chang Q, et al. Neoplasia. 2013 Jul;15(7):848-62. doi: 10.1593/neo.13706. Neoplasia. 2013. PMID: 23814496 Free PMC article.
45 results