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Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.
Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, DeBiasi RM, Yoshimoto K, King JC, Nghiemphu P, Yuza Y, Xu Q, Greulich H, Thomas RK, Paez JG, Peck TC, Linhart DJ, Glatt KA, Getz G, Onofrio R, Ziaugra L, Levine RL, Gabriel S, Kawaguchi T, O'Neill K, Khan H, Liau LM, Nelson SF, Rao PN, Mischel P, Pieper RO, Cloughesy T, Leahy DJ, Sellers WR, Sawyers CL, Meyerson M, Mellinghoff IK. Lee JC, et al. Among authors: leahy dj. PLoS Med. 2006 Dec;3(12):e485. doi: 10.1371/journal.pmed.0030485. PLoS Med. 2006. PMID: 17177598 Free PMC article.
How IGF-1 activates its receptor.
Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. Kavran JM, et al. Among authors: leahy dj. Elife. 2014 Sep 25;3:e03772. doi: 10.7554/eLife.03772. Elife. 2014. PMID: 25255214 Free PMC article.
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Qiu C, et al. Among authors: leahy dj. Structure. 2008 Mar;16(3):460-7. doi: 10.1016/j.str.2007.12.016. Structure. 2008. PMID: 18334220 Free PMC article.
An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.
Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA. Chiang MJ, et al. Among authors: leahy dj. J Am Chem Soc. 2014 Mar 5;136(9):3370-3. doi: 10.1021/ja5006674. Epub 2014 Feb 24. J Am Chem Soc. 2014. PMID: 24533830 Free PMC article.
Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.
Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Wang Y, et al. Among authors: leahy dj. J Biol Chem. 2014 Nov 7;289(45):31361-72. doi: 10.1074/jbc.M114.597153. Epub 2014 Sep 23. J Biol Chem. 2014. PMID: 25248746 Free PMC article.
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor.
Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA. Barnett BP, et al. Among authors: leahy dj. Science. 2010 Dec 17;330(6011):1689-92. doi: 10.1126/science.1196154. Epub 2010 Nov 18. Science. 2010. PMID: 21097901 Free PMC article.
112 results