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Granzyme K drives a newly-intentified pathway of complement activation.
Donado CA, Jonsson AH, Theisen E, Zhang F, Nathan A, Rupani KV, Jones D; Accelerating Medicines Partnership RA/SLE Network; Raychaudhuri S, Dwyer DF, Brenner MB. Donado CA, et al. Among authors: brenner mb. bioRxiv [Preprint]. 2024 May 26:2024.05.22.595315. doi: 10.1101/2024.05.22.595315. bioRxiv. 2024. PMID: 38826230 Free PMC article. Preprint.
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.
Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S. Weinand K, et al. Among authors: brenner mb. Nat Commun. 2024 May 31;15(1):4650. doi: 10.1038/s41467-024-48620-7. Nat Commun. 2024. PMID: 38821936 Free PMC article.
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.
Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH; Accelerating Medicines Partnership RA/SLE Network; Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE. Bai Z, et al. Sci Transl Med. 2024 Apr 10;16(742):eadk3506. doi: 10.1126/scitranslmed.adk3506. Epub 2024 Apr 10. Sci Transl Med. 2024. PMID: 38598614
Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.
Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z; Accelerating Medicines Partnership® RA/SLE Program and Network; Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S. Sakaue S, et al. Among authors: brenner mb. Nat Genet. 2024 Apr;56(4):615-626. doi: 10.1038/s41588-024-01682-1. Epub 2024 Apr 9. Nat Genet. 2024. PMID: 38594305
Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis.
Horisberger A, Griffith A, Keegan J, Arazi A, Pulford J, Murzin E, Howard K, Hancock B, Fava A, Sasaki T, Ghosh T, Inamo J, Beuschel R, Cao Y, Preisinger K, Gutierrez-Arcelus M, Eisenhaure TM, Guthridge J, Hoover PJ, Dall'Era M, Wofsy D, Kamen DL, Kalunian KC, Furie R, Belmont M, Izmirly P, Clancy R, Hildeman D, Woodle ES, Apruzzese W, McMahon MA, Grossman J, Barnas JL, Payan-Schober F, Ishimori M, Weisman M, Kretzler M, Berthier CC, Hodgin JB, Demeke DS, Putterman C; Accelerating Medicines Partnership: RA/SLE Network; Brenner MB, Anolik JH, Raychaudhuri S, Hacohen N, James JA, Davidson A, Petri MA, Buyon JP, Diamond B, Zhang F, Lederer JA, Rao DA. Horisberger A, et al. Among authors: brenner mb. bioRxiv [Preprint]. 2024 Mar 9:2024.01.14.575609. doi: 10.1101/2024.01.14.575609. bioRxiv. 2024. PMID: 38293222 Free PMC article. Preprint.
MultipleXed Population Selection and Enrichment single nucleus RNA sequencing (XPoSE-seq) enables sample identity retention during transcriptional profiling of rare populations.
Savell KE, Madangopal R, Saravanan P, Palaganas RG, Woods KD, Thompson DJ, Drake OR, Brenner MB, Weber SJ, Van Leer E, Choi JH, Martin TL, Martin JC, Steinberg MK, Austin JW, Charendoff CI, Hope BT. Savell KE, et al. Among authors: brenner mb. bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559834. doi: 10.1101/2023.09.27.559834. bioRxiv. 2023. PMID: 38196637 Free PMC article. Preprint.
333 results