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Page 1
Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs.
Beconi MG, Reed JR, Teffera Y, Xia YQ, Kochansky CJ, Liu DQ, Xu S, Elmore CS, Ciccotto S, Hora DF, Stearns RA, Vincent SH. Beconi MG, et al. Among authors: vincent sh. Drug Metab Dispos. 2007 Apr;35(4):525-32. doi: 10.1124/dmd.106.013110. Epub 2007 Jan 12. Drug Metab Dispos. 2007. PMID: 17220241
Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.
Reddy VB, Doss GA, Creighton M, Kochansky CJ, Vincent SH, Franklin RB, Karanam BV. Reddy VB, et al. Among authors: vincent sh. Drug Metab Dispos. 2004 Oct;32(10):1154-61. doi: 10.1124/dmd.104.000240. Epub 2004 Jun 30. Drug Metab Dispos. 2004. PMID: 15229171
Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.
Anari MR, Creighton MD, Ngui JS, Tschirret-Guth RA, Teffera Y, Doss GA, Tang W, Yu NX, Ciccotto SL, Hobra DF Jr, Coleman JB, Vincent SH, Evans DC. Anari MR, et al. Among authors: vincent sh. Drug Metab Dispos. 2006 Aug;34(8):1367-75. doi: 10.1124/dmd.105.009027. Epub 2006 May 12. Drug Metab Dispos. 2006. PMID: 16698892
Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.
Kochansky CJ, Rippley RK, Yan KX, Song H, Wallace MA, Dean D, Jones AN, Lasseter K, Schwartz J, Vincent SH, Franklin RB, Wagner J. Kochansky CJ, et al. Among authors: vincent sh. Drug Metab Dispos. 2006 Sep;34(9):1457-61. doi: 10.1124/dmd.106.010231. Epub 2006 Jun 13. Drug Metab Dispos. 2006. PMID: 16772365 Clinical Trial.
Characterization of two cyclic metabolites of sitagliptin.
Liu DQ, Arison BH, Stearns RA, Kim D, Vincent SH. Liu DQ, et al. Among authors: vincent sh. Drug Metab Dispos. 2007 Apr;35(4):521-4. doi: 10.1124/dmd.106.013128. Epub 2007 Jan 12. Drug Metab Dispos. 2007. PMID: 17220240
80 results