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Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.
Bonta PI, van Tiel CM, Vos M, Pols TW, van Thienen JV, Ferreira V, Arkenbout EK, Seppen J, Spek CA, van der Poll T, Pannekoek H, de Vries CJ. Bonta PI, et al. Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2288-94. doi: 10.1161/01.ATV.0000238346.84458.5d. Epub 2006 Jul 27. Arterioscler Thromb Vasc Biol. 2006. PMID: 16873729
p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
van Tiel CM, Bonta PI, Rittersma SZ, Beijk MA, Bradley EJ, Klous AM, Koch KT, Baas F, Jukema JW, Pons D, Sampietro ML, Pannekoek H, de Winter RJ, de Vries CJ. van Tiel CM, et al. Among authors: bonta pi. Circulation. 2009 Aug 25;120(8):669-76. doi: 10.1161/CIRCULATIONAHA.108.842179. Epub 2009 Aug 10. Circulation. 2009. PMID: 19667240
Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation.
Bonta PI, Pols TW, van Tiel CM, Vos M, Arkenbout EK, Rohlena J, Koch KT, de Maat MP, Tanck MW, de Winter RJ, Pannekoek H, Biessen EA, Bot I, de Vries CJ. Bonta PI, et al. Circulation. 2010 May 11;121(18):2023-32. doi: 10.1161/CIRCULATIONAHA.109.885673. Epub 2010 Apr 26. Circulation. 2010. PMID: 20421523
Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo.
Schepers A, Eefting D, Bonta PI, Grimbergen JM, de Vries MR, van Weel V, de Vries CJ, Egashira K, van Bockel JH, Quax PH. Schepers A, et al. Among authors: bonta pi. Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2063-9. doi: 10.1161/01.ATV.0000235694.69719.e2. Epub 2006 Jul 6. Arterioscler Thromb Vasc Biol. 2006. PMID: 16825596
6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages.
Pols TW, Bonta PI, Pires NM, Otermin I, Vos M, de Vries MR, van Eijk M, Roelofsen J, Havekes LM, Quax PH, van Kuilenburg AB, de Waard V, Pannekoek H, de Vries CJ. Pols TW, et al. Among authors: bonta pi. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1591-7. doi: 10.1161/ATVBAHA.110.205674. Epub 2010 Apr 22. Arterioscler Thromb Vasc Biol. 2010. PMID: 20413732
115 results