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Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, Lowell AM, Minami Y, McNamara K, Perera SA, Zaghlul S, Thomas RK, Greulich H, Kobayashi S, Chirieac LR, Padera RF, Kubo S, Takahashi M, Tenen DG, Meyerson M, Wong KK, Shapiro GI. Shimamura T, et al. Among authors: takahashi m. Cancer Res. 2008 Jul 15;68(14):5827-38. doi: 10.1158/0008-5472.CAN-07-5428. Cancer Res. 2008. PMID: 18632637 Free PMC article.
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Li D, Shimamura T, Ji H, Chen L, Haringsma HJ, McNamara K, Liang MC, Perera SA, Zaghlul S, Borgman CL, Kubo S, Takahashi M, Sun Y, Chirieac LR, Padera RF, Lindeman NI, Jänne PA, Thomas RK, Meyerson ML, Eck MJ, Engelman JA, Shapiro GI, Wong KK. Li D, et al. Among authors: takahashi m. Cancer Cell. 2007 Jul;12(1):81-93. doi: 10.1016/j.ccr.2007.06.005. Cancer Cell. 2007. PMID: 17613438 Free article.
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.
Perera SA, Li D, Shimamura T, Raso MG, Ji H, Chen L, Borgman CL, Zaghlul S, Brandstetter KA, Kubo S, Takahashi M, Chirieac LR, Padera RF, Bronson RT, Shapiro GI, Greulich H, Meyerson M, Guertler U, Chesa PG, Solca F, Wistuba II, Wong KK. Perera SA, et al. Among authors: takahashi m. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9. doi: 10.1073/pnas.0808930106. Epub 2009 Jan 2. Proc Natl Acad Sci U S A. 2009. PMID: 19122144 Free PMC article.
TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
Gong K, Guo G, Gerber DE, Gao B, Peyton M, Huang C, Minna JD, Hatanpaa KJ, Kernstine K, Cai L, Xie Y, Zhu H, Fattah FJ, Zhang S, Takahashi M, Mukherjee B, Burma S, Dowell J, Dao K, Papadimitrakopoulou VA, Olivas V, Bivona TG, Zhao D, Habib AA. Gong K, et al. Among authors: takahashi m. J Clin Invest. 2018 Jun 1;128(6):2500-2518. doi: 10.1172/JCI96148. Epub 2018 May 7. J Clin Invest. 2018. PMID: 29613856 Free PMC article.
MR microscopy of the lung in small rodents.
Takahashi M, Kubo S, Kiryu S, Gee J, Hatabu H. Takahashi M, et al. Eur J Radiol. 2007 Dec;64(3):367-74. doi: 10.1016/j.ejrad.2007.08.011. Epub 2007 Sep 27. Eur J Radiol. 2007. PMID: 17904321 Review.
Phosphoprotein-based biomarkers as predictors for cancer therapy.
Carter AM, Tan C, Pozo K, Telange R, Molinaro R, Guo A, De Rosa E, Martinez JO, Zhang S, Kumar N, Takahashi M, Wiederhold T, Ghayee HK, Oltmann SC, Pacak K, Woltering EA, Hatanpaa KJ, Nwariaku FE, Grubbs EG, Gill AJ, Robinson B, Gillardon F, Reddy S, Jaskula-Sztul R, Mobley JA, Mukhtar MS, Tasciotti E, Chen H, Bibb JA. Carter AM, et al. Among authors: takahashi m. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18401-18411. doi: 10.1073/pnas.2010103117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690709 Free PMC article.
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