Harriman GC - Search Results

1

Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.

Jenkins TJ, Guan B, Dai M, Li G, Lightburn TE, Huang S, Freeze BS, Burdi DF, Jacutin-Porte S, Bennett R, Chen W, Minor C, Ghosh S, Blackburn C, Gigstad KM, Jones M, Kolbeck R, Yin W, Smith S, Cardillo D, Ocain TD, Harriman GC. Jenkins TJ, et al. Among authors: harriman gc. J Med Chem. 2007 Feb 8;50(3):566-84. doi: 10.1021/jm061118e. J Med Chem. 2007. PMID: 17266208

2

Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.

Harriman GC, Poirot AF, Abushanab E, Midgett RM, Stoeckler JD. Harriman GC, et al. J Med Chem. 1992 Oct 30;35(22):4180-4. doi: 10.1021/jm00100a025. J Med Chem. 1992. PMID: 1433220

3

Adenosine deaminase inhibitors. Synthesis and biological evaluation of 4-amino-1-(2(S)-hydroxy-3(R)-nonyl)-1H-imidazo[4,5-c]pyridine (3-deaza-(+)-EHNA) and certain C1' derivatives.

Harriman GC, Abushanab E, Stoeckler JD. Harriman GC, et al. J Med Chem. 1994 Jan 21;37(2):305-8. doi: 10.1021/jm00028a014. J Med Chem. 1994. PMID: 8295218

4

Cell adhesion antagonists: synthesis and evaluation of a novel series of phenylalanine based inhibitors.

Harriman GC, Schwender CF, Gallant D, Cochran NA, Briskin MJ. Harriman GC, et al. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1497-9. doi: 10.1016/s0960-894x(00)00300-0. Bioorg Med Chem Lett. 2000. PMID: 10915035

5

Synthesis of 3-amino-1,2,4-benzothiadi- azine 1,1-dioxides via a tandem aza-Wittig/heterocumulene annulation.

Blackburn C, Achab A, Elder A, Ghosh S, Guo J, Harriman G, Jones M. Blackburn C, et al. J Org Chem. 2005 Nov 25;70(24):10206-9. doi: 10.1021/jo051843h. J Org Chem. 2005. PMID: 16292875

6

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.

Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L, Hepperle M, Harriman G, Jaffee BD, Ocain TD, Xu Y. Wen D, et al. J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001. doi: 10.1124/jpet.105.097584. Epub 2006 Mar 8. J Pharmacol Exp Ther. 2006. PMID: 16525037

7

Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).

Ghosh S, Elder A, Guo J, Mani U, Patane M, Carson K, Ye Q, Bennett R, Chi S, Jenkins T, Guan B, Kolbeck R, Smith S, Zhang C, LaRosa G, Jaffee B, Yang H, Eddy P, Lu C, Uttamsingh V, Horlick R, Harriman G, Flynn D. Ghosh S, et al. J Med Chem. 2006 May 4;49(9):2669-72. doi: 10.1021/jm050965z. J Med Chem. 2006. PMID: 16640325

8

IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.

Schopf L, Savinainen A, Anderson K, Kujawa J, DuPont M, Silva M, Siebert E, Chandra S, Morgan J, Gangurde P, Wen D, Lane J, Xu Y, Hepperle M, Harriman G, Ocain T, Jaffee B. Schopf L, et al. Arthritis Rheum. 2006 Oct;54(10):3163-73. doi: 10.1002/art.22081. Arthritis Rheum. 2006. PMID: 17009244 Free article.

9

Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.

Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B. Izmailova ES, et al. Arthritis Rheum. 2007 Jan;56(1):117-28. doi: 10.1002/art.22303. Arthritis Rheum. 2007. PMID: 17195214 Free article.

10

Small molecule antagonists of the CC chemokine receptor 4 (CCR4).

Burdi DF, Chi S, Mattia K, Harrington C, Shi Z, Chen S, Jacutin-Porte S, Bennett R, Carson K, Yin W, Kansra V, Gonzalo JA, Coyle A, Jaffee B, Ocain T, Hodge M, LaRosa G, Harriman G. Burdi DF, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3141-5. doi: 10.1016/j.bmcl.2007.03.030. Epub 2007 Mar 15. Bioorg Med Chem Lett. 2007. PMID: 17395464

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