Zhang C - Search Results

1

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Blair JA, et al. Among authors: zhang c. Nat Chem Biol. 2007 Apr;3(4):229-38. doi: 10.1038/nchembio866. Epub 2007 Mar 4. Nat Chem Biol. 2007. PMID: 17334377

2

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.

Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Zhang C, et al. ACS Chem Biol. 2013 Sep 20;8(9):1931-8. doi: 10.1021/cb400376p. Epub 2013 Jul 23. ACS Chem Biol. 2013. PMID: 23841803 Free PMC article.

3

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. Poulikakos PI, et al. Among authors: zhang c. Nature. 2010 Mar 18;464(7287):427-30. doi: 10.1038/nature08902. Nature. 2010. PMID: 20179705 Free PMC article.

4

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.

Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Tan YX, et al. Among authors: zhang c. Nat Immunol. 2014 Feb;15(2):186-94. doi: 10.1038/ni.2772. Epub 2013 Dec 8. Nat Immunol. 2014. PMID: 24317039 Free PMC article.

5

Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.

Fan QW, Zhang C, Shokat KM, Weiss WA. Fan QW, et al. Among authors: zhang c. Curr Biol. 2002 Aug 20;12(16):1386-94. doi: 10.1016/s0960-9822(02)01070-9. Curr Biol. 2002. PMID: 12194819 Free article.

6

Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.

Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. Fan QW, et al. Among authors: zhang c. Cancer Res. 2003 Dec 15;63(24):8930-8. Cancer Res. 2003. PMID: 14695210

7

A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.

Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. Zhang C, et al. Nat Methods. 2005 Jun;2(6):435-41. doi: 10.1038/nmeth764. Nat Methods. 2005. PMID: 15908922

8

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

Cohen MS, Zhang C, Shokat KM, Taunton J. Cohen MS, et al. Among authors: zhang c. Science. 2005 May 27;308(5726):1318-21. doi: 10.1126/science1108367. Science. 2005. PMID: 15919995 Free PMC article.

9

Chemical genetic engineering of G protein-coupled receptor kinase 2.

Kenski DM, Zhang C, von Zastrow M, Shokat KM. Kenski DM, et al. Among authors: zhang c. J Biol Chem. 2005 Oct 14;280(41):35051-61. doi: 10.1074/jbc.M507594200. Epub 2005 Aug 4. J Biol Chem. 2005. PMID: 16081410 Free article.

10

Design and use of analog-sensitive protein kinases.

Blethrow J, Zhang C, Shokat KM, Weiss EL. Blethrow J, et al. Among authors: zhang c. Curr Protoc Mol Biol. 2004 May;Chapter 18:Unit 18.11. doi: 10.1002/0471142727.mb1811s66. Curr Protoc Mol Biol. 2004. PMID: 18265343

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