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Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.
Pero RS, Borchers MT, Spicher K, Ochkur SI, Sikora L, Rao SP, Abdala-Valencia H, O'Neill KR, Shen H, McGarry MP, Lee NA, Cook-Mills JM, Sriramarao P, Simon MI, Birnbaumer L, Lee JJ. Pero RS, et al. Among authors: shen h. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4371-6. doi: 10.1073/pnas.0700185104. Epub 2007 Mar 7. Proc Natl Acad Sci U S A. 2007. PMID: 17360531 Free PMC article.
Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology.
Justice JP, Borchers MT, Crosby JR, Hines EM, Shen HH, Ochkur SI, McGarry MP, Lee NA, Lee JJ. Justice JP, et al. Among authors: shen hh. Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L169-78. doi: 10.1152/ajplung.00260.2002. Epub 2002 Sep 13. Am J Physiol Lung Cell Mol Physiol. 2003. PMID: 12388345 Free article.
Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma.
Ochkur SI, Jacobsen EA, Protheroe CA, Biechele TL, Pero RS, McGarry MP, Wang H, O'Neill KR, Colbert DC, Colby TV, Shen H, Blackburn MR, Irvin CC, Lee JJ, Lee NA. Ochkur SI, et al. Among authors: shen h. J Immunol. 2007 Jun 15;178(12):7879-89. doi: 10.4049/jimmunol.178.12.7879. J Immunol. 2007. PMID: 17548626
Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation.
Ochkur SI, Doyle AD, Jacobsen EA, LeSuer WE, Li W, Protheroe CA, Zellner KR, Colbert D, Shen HH, Irvin CG, Lee JJ, Lee NA. Ochkur SI, et al. Among authors: shen hh. J Leukoc Biol. 2017 Sep;102(3):589-599. doi: 10.1189/jlb.3HI1116-488RR. Epub 2017 May 17. J Leukoc Biol. 2017. PMID: 28515227 Free PMC article.
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