Grundler R - Search Results

1

Flt3-dependent transformation by inactivating c-Cbl mutations in AML.

Sargin B, Choudhary C, Crosetto N, Schmidt MHH, Grundler R, Rensinghoff M, Thiessen C, Tickenbrock L, Schwäble J, Brandts C, August B, Koschmieder S, Bandi SR, Duyster J, Berdel WE, Müller-Tidow C, Dikic I, Serve H. Sargin B, et al. Among authors: grundler r. Blood. 2007 Aug 1;110(3):1004-12. doi: 10.1182/blood-2007-01-066076. Epub 2007 Apr 19. Blood. 2007. PMID: 17446348 Free article. Clinical Trial.

2

Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.

Grundler R, Thiede C, Miething C, Steudel C, Peschel C, Duyster J. Grundler R, et al. Blood. 2003 Jul 15;102(2):646-51. doi: 10.1182/blood-2002-11-3441. Epub 2003 Mar 27. Blood. 2003. PMID: 12663439 Free article.

3

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

Bandi SR, Brandts C, Rensinghoff M, Grundler R, Tickenbrock L, Köhler G, Duyster J, Berdel WE, Müller-Tidow C, Serve H, Sargin B; Study Alliance Leukemias. Bandi SR, et al. Among authors: grundler r. Blood. 2009 Nov 5;114(19):4197-208. doi: 10.1182/blood-2008-12-190934. Epub 2009 Sep 4. Blood. 2009. PMID: 19734451 Free article.

4

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.

Grundler R, Miething C, Thiede C, Peschel C, Duyster J. Grundler R, et al. Blood. 2005 Jun 15;105(12):4792-9. doi: 10.1182/blood-2004-11-4430. Epub 2005 Feb 17. Blood. 2005. PMID: 15718420 Free article.

5

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor.

Breitenbuecher F, Schnittger S, Grundler R, Markova B, Carius B, Brecht A, Duyster J, Haferlach T, Huber C, Fischer T. Breitenbuecher F, et al. Among authors: grundler r. Blood. 2009 Apr 23;113(17):4074-7. doi: 10.1182/blood-2007-11-125476. Epub 2008 May 15. Blood. 2009. PMID: 18483393 Free article.

6

SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML.

Leischner H, Albers C, Grundler R, Razumovskaya E, Spiekermann K, Bohlander S, Rönnstrand L, Götze K, Peschel C, Duyster J. Leischner H, et al. Among authors: grundler r. Blood. 2012 Apr 26;119(17):4026-33. doi: 10.1182/blood-2011-07-365726. Epub 2012 Mar 12. Blood. 2012. PMID: 22411868 Free article.

7

Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations.

Kancha RK, Grundler R, Peschel C, Duyster J. Kancha RK, et al. Among authors: grundler r. Exp Hematol. 2007 Oct;35(10):1522-6. doi: 10.1016/j.exphem.2007.07.008. Exp Hematol. 2007. PMID: 17889720 Free article.

8

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice.

Gorantla SP, Dechow TN, Grundler R, Illert AL, Zum Büschenfelde CM, Kremer M, Peschel C, Duyster J. Gorantla SP, et al. Among authors: grundler r. Blood. 2010 Nov 25;116(22):4600-11. doi: 10.1182/blood-2009-07-236133. Epub 2010 Aug 9. Blood. 2010. PMID: 20696946 Free article.

9

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.

Gerloff D, Grundler R, Wurm AA, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Madan V, Müller-Tidow C, Duyster J, Tenen DG, Niederwieser D, Behre G. Gerloff D, et al. Among authors: grundler r. Leukemia. 2015 Mar;29(3):535-47. doi: 10.1038/leu.2014.231. Epub 2014 Aug 5. Leukemia. 2015. PMID: 25092144 Free PMC article.

10

Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro.

Heidel F, Lipka DB, Mirea FK, Mahboobi S, Grundler R, Kancha RK, Duyster J, Naumann M, Huber C, Böhmer FD, Fischer T. Heidel F, et al. Among authors: grundler r. Br J Haematol. 2009 Mar;144(6):865-74. doi: 10.1111/j.1365-2141.2008.07567.x. Epub 2009 Jan 16. Br J Haematol. 2009. PMID: 19183186 Free article.

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