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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.
Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN. Lyon HN, et al. Among authors: nguyen tt. PLoS Genet. 2007 Apr 27;3(4):e61. doi: 10.1371/journal.pgen.0030061. Epub 2007 Mar 7. PLoS Genet. 2007. PMID: 17465681 Free PMC article.
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE. Heid IM, et al. Among authors: nguyen tt. PLoS Genet. 2009 Oct;5(10):e1000694. doi: 10.1371/journal.pgen.1000694. Epub 2009 Oct 23. PLoS Genet. 2009. PMID: 19851442 Free PMC article.
No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.
Müller TD, Reichwald K, Wermter AK, Brönner G, Nguyen TT, Friedel S, Koberwitz K, Engeli S, Lichtner P, Meitinger T, Schäfer H, Hebebrand J, Hinney A. Müller TD, et al. Among authors: nguyen tt. Mol Genet Metab. 2007 Apr;90(4):429-34. doi: 10.1016/j.ymgme.2007.01.002. Epub 2007 Feb 8. Mol Genet Metab. 2007. PMID: 17292652
Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.
Hinney A, Bettecken T, Tarnow P, Brumm H, Reichwald K, Lichtner P, Scherag A, Nguyen TT, Schlumberger P, Rief W, Vollmert C, Illig T, Wichmann HE, Schäfer H, Platzer M, Biebermann H, Meitinger T, Hebebrand J. Hinney A, et al. Among authors: nguyen tt. J Clin Endocrinol Metab. 2006 May;91(5):1761-9. doi: 10.1210/jc.2005-2056. Epub 2006 Feb 21. J Clin Endocrinol Metab. 2006. PMID: 16492696
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.
Wermter AK, Scherag A, Meyre D, Reichwald K, Durand E, Nguyen TT, Koberwitz K, Lichtner P, Meitinger T, Schäfer H, Hinney A, Froguel P, Hebebrand J, Brönner G. Wermter AK, et al. Among authors: nguyen tt. Eur J Hum Genet. 2008 Sep;16(9):1126-34. doi: 10.1038/ejhg.2008.64. Epub 2008 Apr 9. Eur J Hum Genet. 2008. PMID: 18398438
Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa.
Müller TD, Reichwald K, Brönner G, Kirschner J, Nguyen TT, Scherag A, Herzog W, Herpertz-Dahlmann B, Lichtner P, Meitinger T, Platzer M, Schäfer H, Hebebrand J, Hinney A. Müller TD, et al. Among authors: nguyen tt. Child Adolesc Psychiatry Ment Health. 2008 Nov 17;2(1):33. doi: 10.1186/1753-2000-2-33. Child Adolesc Psychiatry Ment Health. 2008. PMID: 19014633 Free PMC article.
Genome-wide association study in German patients with attention deficit/hyperactivity disorder.
Hinney A, Scherag A, Jarick I, Albayrak Ö, Pütter C, Pechlivanis S, Dauvermann MR, Beck S, Weber H, Scherag S, Nguyen TT, Volckmar AL, Knoll N, Faraone SV, Neale BM, Franke B, Cichon S, Hoffmann P, Nöthen MM, Schreiber S, Jöckel KH, Wichmann HE, Freitag C, Lempp T, Meyer J, Gilsbach S, Herpertz-Dahlmann B, Sinzig J, Lehmkuhl G, Renner TJ, Warnke A, Romanos M, Lesch KP, Reif A, Schimmelmann BG, Hebebrand J; Psychiatric GWAS Consortium: ADHD subgroup. Hinney A, et al. Among authors: nguyen tt. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):888-97. doi: 10.1002/ajmg.b.31246. Epub 2011 Oct 19. Am J Med Genet B Neuropsychiatr Genet. 2011. PMID: 22012869
Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis.
Dempfle A, Hein R, Beckmann L, Scherag A, Nguyen TT, Schäfer H, Chang-Claude J. Dempfle A, et al. Among authors: nguyen tt. BMC Proc. 2007;1 Suppl 1(Suppl 1):S73. doi: 10.1186/1753-6561-1-s1-s73. Epub 2007 Dec 18. BMC Proc. 2007. PMID: 18466575 Free PMC article.
4,088 results