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Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. Fong LG, et al. Among authors: farber ea. Hum Mol Genet. 2009 Jul 1;18(13):2462-71. doi: 10.1093/hmg/ddp184. Epub 2009 Apr 17. Hum Mol Genet. 2009. PMID: 19376814 Free PMC article.
Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. Coffinier C, et al. Among authors: farber ea. J Biol Chem. 2010 Jul 2;285(27):20818-26. doi: 10.1074/jbc.M110.128835. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439468 Free PMC article.
69 results