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Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.
Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Leprêtre F, Dupont S, Hara K, Clément K, Bihain B, Kadowaki T, Froguel P. Vasseur F, et al. Among authors: froguel p. Hum Mol Genet. 2002 Oct 1;11(21):2607-14. doi: 10.1093/hmg/11.21.2607. Hum Mol Genet. 2002. PMID: 12354786
Genetics of obesity.
Clement K, Boutin P, Froguel P. Clement K, et al. Among authors: froguel p. Am J Pharmacogenomics. 2002;2(3):177-87. doi: 10.2165/00129785-200202030-00003. Am J Pharmacogenomics. 2002. PMID: 12383024 Review.
Molecular genetics of human obesity-associated MC4R mutations.
Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C. Lubrano-Berthelier C, et al. Among authors: froguel p. Ann N Y Acad Sci. 2003 Jun;994:49-57. doi: 10.1111/j.1749-6632.2003.tb03161.x. Ann N Y Acad Sci. 2003. PMID: 12851297 Review.
GAD2 on chromosome 10p12 is a candidate gene for human obesity.
Boutin P, Dina C, Vasseur F, Dubois S, Corset L, Séron K, Bekris L, Cabellon J, Neve B, Vasseur-Delannoy V, Chikri M, Charles MA, Clement K, Lernmark A, Froguel P. Boutin P, et al. Among authors: froguel p. PLoS Biol. 2003 Dec;1(3):E68. doi: 10.1371/journal.pbio.0000068. Epub 2003 Nov 3. PLoS Biol. 2003. PMID: 14691540 Free PMC article.
Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.
Fumeron F, Aubert R, Siddiq A, Betoulle D, Péan F, Hadjadj S, Tichet J, Wilpart E, Chesnier MC, Balkau B, Froguel P, Marre M; Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group. Fumeron F, et al. Among authors: froguel p. Diabetes. 2004 Apr;53(4):1150-7. doi: 10.2337/diabetes.53.4.1150. Diabetes. 2004. PMID: 15047634
793 results