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Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Hevener AL, et al. Among authors: febbraio ma. J Clin Invest. 2007 Jun;117(6):1658-69. doi: 10.1172/JCI31561. Epub 2007 May 24. J Clin Invest. 2007. PMID: 17525798 Free PMC article.
HSP72 protects against obesity-induced insulin resistance.
Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA. Chung J, et al. Among authors: febbraio ma. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44. doi: 10.1073/pnas.0705799105. Epub 2008 Jan 25. Proc Natl Acad Sci U S A. 2008. PMID: 18223156 Free PMC article.
Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.
Henstridge DC, Bruce CR, Drew BG, Tory K, Kolonics A, Estevez E, Chung J, Watson N, Gardner T, Lee-Young RS, Connor T, Watt MJ, Carpenter K, Hargreaves M, McGee SL, Hevener AL, Febbraio MA. Henstridge DC, et al. Among authors: febbraio ma. Diabetes. 2014 Jun;63(6):1881-94. doi: 10.2337/db13-0967. Epub 2014 Jan 15. Diabetes. 2014. PMID: 24430435 Free PMC article.
291 results