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A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.
Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. Shanmugam R, et al. Among authors: neelakantan s. Int J Cancer. 2011 May 15;128(10):2481-94. doi: 10.1002/ijc.25587. Int J Cancer. 2011. PMID: 20669221 Free PMC article.
Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer.
Vegeler RC, Yip-Schneider MT, Ralstin M, Wu H, Crooks PA, Neelakantan S, Nakshatri H, Sweeney CJ, Schmidt CM. Vegeler RC, et al. Among authors: neelakantan s. J Surg Res. 2007 Nov;143(1):169-76. doi: 10.1016/j.jss.2007.08.007. Epub 2007 Aug 31. J Surg Res. 2007. PMID: 17950089
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, Crooks PA, Jordan CT. Guzman ML, et al. Among authors: neelakantan s. Blood. 2007 Dec 15;110(13):4427-35. doi: 10.1182/blood-2007-05-090621. Epub 2007 Sep 5. Blood. 2007. PMID: 17804695 Free PMC article.
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK, Pratt G, Fegan C, Rowntree C, Brennan P, Pepper C. Hewamana S, et al. Among authors: neelakantan s. Blood. 2008 May 1;111(9):4681-9. doi: 10.1182/blood-2007-11-125278. Epub 2008 Jan 28. Blood. 2008. PMID: 18227347 Free article.
72 results