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Page 1
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
Wickens P, Kluender H, Dixon J, Brennan C, Achebe F, Bacchiocchi A, Bankston D, Bierer D, Brands M, Braun D, Brown MS, Chuang CY, Dumas J, Enyedy I, Hofilena G, Hong Z, Housley T, Jones B, Khire U, Kreiman C, Kumarasinghe E, Lowinger T, Ott-Morgan R, Perkins L, Phillips B, Schoenleber R, Scott WJ, Sheeler R, Redman A, Sun X, Taylor I, Wang L, Wilhelm S, Zhang X, Zhang M, Sullivan E, Carter C, Miglarese M, Levy J. Wickens P, et al. Among authors: kluender h. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4378-81. doi: 10.1016/j.bmcl.2007.02.075. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17574417
Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.
Smith RA, Fathi Z, Achebe F, Akuche C, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Su N, Taing C, Tomlinson S, Tritto T, Wang G, Wirtz SN, Wong W, Yang XF, Ying S, Zhang Z. Smith RA, et al. Among authors: kluender hc. Bioorg Med Chem Lett. 2007 May 15;17(10):2706-11. doi: 10.1016/j.bmcl.2007.03.011. Epub 2007 Mar 12. Bioorg Med Chem Lett. 2007. PMID: 17383180
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.
Lowe DB, Magnuson S, Qi N, Campbell AM, Cook J, Hong Z, Wang M, Rodriguez M, Achebe F, Kluender H, Wong WC, Bullock WH, Salhanick AI, Witman-Jones T, Bowling ME, Keiper C, Clairmont KB. Lowe DB, et al. Among authors: kluender h. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3155-9. doi: 10.1016/j.bmcl.2004.04.015. Bioorg Med Chem Lett. 2004. PMID: 15149665
Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.
Smith RA, Fathi Z, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Podlogar B, Taing C, Tomlinson S, Tritto T, Zhang Z. Smith RA, et al. Among authors: kluender hc. Bioorg Med Chem Lett. 2007 Feb 1;17(3):673-8. doi: 10.1016/j.bmcl.2006.10.095. Epub 2006 Nov 2. Bioorg Med Chem Lett. 2007. PMID: 17107792
Discovery and synthesis of rioprostil.
Kluender H, Corey P. Kluender H, et al. Scand J Gastroenterol Suppl. 1989;164:1-8; discussion 8-9. doi: 10.3109/00365528909091179. Scand J Gastroenterol Suppl. 1989. PMID: 2510251
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