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SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
Wickens P, Kluender H, Dixon J, Brennan C, Achebe F, Bacchiocchi A, Bankston D, Bierer D, Brands M, Braun D, Brown MS, Chuang CY, Dumas J, Enyedy I, Hofilena G, Hong Z, Housley T, Jones B, Khire U, Kreiman C, Kumarasinghe E, Lowinger T, Ott-Morgan R, Perkins L, Phillips B, Schoenleber R, Scott WJ, Sheeler R, Redman A, Sun X, Taylor I, Wang L, Wilhelm S, Zhang X, Zhang M, Sullivan E, Carter C, Miglarese M, Levy J. Wickens P, et al. Among authors: zhang m, zhang x. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4378-81. doi: 10.1016/j.bmcl.2007.02.075. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17574417
Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.
Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M, Conway B, Mahboubi K, D'Angelo G, Mitschler A, Cousido-Siah A, Ruiz FX, Howard EI, Podjarny AD, Schroeter H. Van Zandt MC, et al. Among authors: zhang m. J Med Chem. 2013 Mar 28;56(6):2568-80. doi: 10.1021/jm400014c. Epub 2013 Mar 8. J Med Chem. 2013. PMID: 23472952
Substituted indanylacetic acids as PPAR-alpha-gamma activators.
Lowe DB, Bifulco N, Bullock WH, Claus T, Coish P, Dai M, Dela Cruz FE, Dickson D, Fan D, Hoover-Litty H, Li T, Ma X, Mannelly G, Monahan MK, Muegge I, O'Connor S, Rodriguez M, Shelekhin T, Stolle A, Sweet L, Wang M, Wang Y, Zhang C, Zhang HJ, Zhang M, Zhao K, Zhao Q, Zhu J, Zhu L, Tsutsumi M. Lowe DB, et al. Among authors: zhang m, zhang c, zhang hj. Bioorg Med Chem Lett. 2006 Jan 15;16(2):297-301. doi: 10.1016/j.bmcl.2005.10.008. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275080
57,407 results
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