Ryan MJ - Search Results

1

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.

Powell NA, Ciske FL, Cai C, Holsworth DD, Mennen K, Van Huis CA, Jalaie M, Day J, Mastronardi M, McConnell P, Mochalkin I, Zhang E, Ryan MJ, Bryant J, Collard W, Ferreira S, Gu C, Collins R, Edmunds JJ. Powell NA, et al. Among authors: ryan mj. Bioorg Med Chem. 2007 Sep 1;15(17):5912-49. doi: 10.1016/j.bmc.2007.05.069. Epub 2007 Jun 2. Bioorg Med Chem. 2007. PMID: 17574423

2

The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors.

Cody WL, Holsworth DD, Powell NA, Jalaie M, Zhang E, Wang W, Samas B, Bryant J, Ostroski R, Ryan MJ, Edmunds JJ. Cody WL, et al. Among authors: ryan mj. Bioorg Med Chem. 2005 Jan 3;13(1):59-68. doi: 10.1016/j.bmc.2004.09.056. Bioorg Med Chem. 2005. PMID: 15582452

3

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.

Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ. Powell NA, et al. Among authors: ryan mj. Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. doi: 10.1016/j.bmcl.2005.02.085. Bioorg Med Chem Lett. 2005. PMID: 15837327

4

Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitors.

Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Edmunds JJ. Powell NA, et al. Among authors: ryan mj. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4713-6. doi: 10.1016/j.bmcl.2005.07.063. Bioorg Med Chem Lett. 2005. PMID: 16143527

5

Ketopiperazine-based renin inhibitors: optimization of the "C" ring.

Holsworth DD, Cai C, Cheng XM, Cody WL, Downing DM, Erasga N, Lee C, Powell NA, Edmunds JJ, Stier M, Jalaie M, Zhang E, McConnell P, Ryan MJ, Bryant J, Li T, Kasani A, Hall E, Subedi R, Rahim M, Maiti S. Holsworth DD, et al. Among authors: ryan mj. Bioorg Med Chem Lett. 2006 May 1;16(9):2500-4. doi: 10.1016/j.bmcl.2006.01.084. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480874

6

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.

Holsworth DD, Jalaie M, Belliotti T, Cai C, Collard W, Ferreira S, Powell NA, Stier M, Zhang E, McConnell P, Mochalkin I, Ryan MJ, Bryant J, Li T, Kasani A, Subedi R, Maiti SN, Edmunds JJ. Holsworth DD, et al. Among authors: ryan mj. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3575-80. doi: 10.1016/j.bmcl.2007.04.052. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17482464

7

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.

Doherty AM, Sircar I, Kornberg BE, Quin J 3rd, Winters RT, Kaltenbronn JS, Taylor MD, Batley BL, Rapundalo SR, Ryan MJ, et al. Doherty AM, et al. Among authors: ryan mj. J Med Chem. 1992 Jan;35(1):2-14. doi: 10.1021/jm00079a001. J Med Chem. 1992. PMID: 1732531

8

Evaluation of physicochemical parameters important to the oral bioavailability of peptide-like compounds: implications for the synthesis of renin inhibitors.

Hamilton HW, Steinbaugh BA, Stewart BH, Chan OH, Schmid HL, Schroeder R, Ryan MJ, Keiser J, Taylor MD, Blankley CJ, et al. Hamilton HW, et al. Among authors: ryan mj. J Med Chem. 1995 Apr 28;38(9):1446-55. doi: 10.1021/jm00009a005. J Med Chem. 1995. PMID: 7739003

9

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: ryan mj. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

10

Orally active water-soluble N,O-acyl transfer products of a beta,gamma-bishydroxyl amide containing renin inhibitor.

Hurley TR, Colson CE, Hicks G, Ryan MJ. Hurley TR, et al. Among authors: ryan mj. J Med Chem. 1993 May 14;36(10):1496-8. doi: 10.1021/jm00062a024. J Med Chem. 1993. PMID: 8496918 No abstract available.

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