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Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants.
Gilliland T, Dunn M, Liu Y, Alcorn MDH, Terada Y, Vasilatos S, Lundy J, Li R, Nambulli S, Larson D, Duprex P, Wu H, Luke T, Bausch C, Egland K, Sullivan E, Wang Z, Klimstra WB. Gilliland T, et al. Among authors: bausch c. iScience. 2023 Aug 29;26(10):107764. doi: 10.1016/j.isci.2023.107764. eCollection 2023 Oct 20. iScience. 2023. PMID: 37736038 Free PMC article.
A fully human monoclonal antibody possesses antibody-dependent cellular cytotoxicity (ADCC) activity against the H1 subtype of influenza A virus by targeting a conserved epitope at the HA1 protomer interface.
Gao R, Wang Z, Uprety T, Sreenivasan CC, Sheng Z, Hause BM, Brunick C, Wu H, Luke T, Bausch CL, Sullivan EJ, Hoppe AD, Huber VC, Wang D, Li F. Gao R, et al. Among authors: bausch cl. J Med Virol. 2023 Jul;95(7):e28901. doi: 10.1002/jmv.28901. J Med Virol. 2023. PMID: 37394780
Polyclonal Antibodies Derived from Transchromosomic Bovines Vaccinated with the Recombinant F1-V Vaccine Increase Bacterial Opsonization In Vitro and Protect Mice from Pneumonic Plague.
Biryukov SS, Wu H, Dankmeyer JL, Rill NO, Klimko CP, Egland KA, Shoe JL, Hunter M, Fetterer DP, Qiu J, Davies ML, Bausch CL, Sullivan EJ, Luke T, Cote CK. Biryukov SS, et al. Among authors: bausch cl. Antibodies (Basel). 2023 May 8;12(2):33. doi: 10.3390/antib12020033. Antibodies (Basel). 2023. PMID: 37218899 Free PMC article.
Phase 2 Safety and Antiviral Activity of SAB-185, a Novel Polyclonal Antibody Therapy for Nonhospitalized Adults With COVID-19.
Taiwo BO, Chew KW, Moser C, Wohl DA, Daar ES, Li JZ, Greninger AL, Bausch C, Luke T, Hoover K, Neytman G, Giganti MJ, Olefsky M, Javan AC, Fletcher CV, Eron JJ, Currier JS, Hughes MD, Smith DM; ACTIV-2/A5401 Study Team. Taiwo BO, et al. Among authors: bausch c. J Infect Dis. 2023 Jul 14;228(2):133-142. doi: 10.1093/infdis/jiad013. J Infect Dis. 2023. PMID: 36661240 Free PMC article. Clinical Trial.
Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine-Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019.
Tang J, Grubbs G, Lee Y, Wu H, Luke TC, Egland KA, Bausch CL, Sullivan EJ, Khurana S. Tang J, et al. Among authors: bausch cl. J Infect Dis. 2022 Sep 4;226(4):655-663. doi: 10.1093/infdis/jiac031. J Infect Dis. 2022. PMID: 35106573 Free PMC article.
Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines.
Gilliland T, Liu Y, Li R, Dunn M, Cottle E, Terada Y, Ryckman Z, Alcorn M, Vasilatos S, Lundy J, Larson D, Wu H, Luke T, Bausch C, Egland K, Sullivan E, Wang Z, Klimstra WB. Gilliland T, et al. Among authors: bausch c. bioRxiv [Preprint]. 2021 Jul 26:2021.07.26.453840. doi: 10.1101/2021.07.26.453840. bioRxiv. 2021. PMID: 34341790 Free PMC article. Preprint.
Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain.
Gao R, Sreenivasan CC, Sheng Z, Hause BM, Zhou B, Wentworth DE, Clement T, Rausch D, Brunick C, Christopher-Hennings J, Wu H, Bausch CL, Sullivan EJ, Hoppe AD, Huber VC, Wang D, Li F. Gao R, et al. Among authors: bausch cl. J Virol. 2020 Oct 27;94(22):e00945-20. doi: 10.1128/JVI.00945-20. Print 2020 Oct 27. J Virol. 2020. PMID: 32847862 Free PMC article.
Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models.
Perley CC, Brocato RL, Wu H, Bausch C, Karmali PP, Vega JB, Cohen MV, Somerville B, Kwilas SA, Principe LM, Shamblin J, Chivukula P, Sullivan E, Hooper JW. Perley CC, et al. Among authors: bausch c. Front Microbiol. 2020 May 7;11:832. doi: 10.3389/fmicb.2020.00832. eCollection 2020. Front Microbiol. 2020. PMID: 32508764 Free PMC article.
26 results