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Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors alpha and delta.
J Med Chem. 2007 Aug 9;50(16):3954-63. doi: 10.1021/jm070511x. Epub 2007 Jul 4.
J Med Chem. 2007.
PMID: 17608467
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.
Shen L, Zhang Y, Wang A, Sieber-McMaster E, Chen X, Pelton P, Xu JZ, Yang M, Zhu P, Zhou L, Reuman M, Hu Z, Russell R, Gibbs AC, Ross H, Demarest K, Murray WV, Kuo GH.
Shen L, et al. Among authors: sieber mcmaster e.
Bioorg Med Chem. 2008 Mar 15;16(6):3321-41. doi: 10.1016/j.bmc.2007.12.005. Epub 2007 Dec 8.
Bioorg Med Chem. 2008.
PMID: 18155554
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Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Zhang R, Deangelis A, Wang A, Sieber-McMaster E, Li X, Russell R, Pelton P, Xu J, Zhu P, Zhou L, Demarest K, Murray WV, Kuo GH.
Zhang R, et al. Among authors: sieber mcmaster e.
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1101-4. doi: 10.1016/j.bmcl.2008.12.113. Epub 2009 Jan 8.
Bioorg Med Chem Lett. 2009.
PMID: 19168353
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Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.
Rano TA, Sieber-McMaster E, Pelton PD, Yang M, Demarest KT, Kuo GH.
Rano TA, et al. Among authors: sieber mcmaster e.
Bioorg Med Chem Lett. 2009 May 1;19(9):2456-60. doi: 10.1016/j.bmcl.2009.03.051. Epub 2009 Mar 18.
Bioorg Med Chem Lett. 2009.
PMID: 19339179
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Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
Mapelli C, Natarajan SI, Meyer JP, Bastos MM, Bernatowicz MS, Lee VG, Pluscec J, Riexinger DJ, Sieber-McMaster ES, Constantine KL, Smith-Monroy CA, Golla R, Ma Z, Longhi DA, Shi D, Xin L, Taylor JR, Koplowitz B, Chi CL, Khanna A, Robinson GW, Seethala R, Antal-Zimanyi IA, Stoffel RH, Han S, Whaley JM, Huang CS, Krupinski J, Ewing WR.
Mapelli C, et al. Among authors: sieber mcmaster es.
J Med Chem. 2009 Dec 10;52(23):7788-99. doi: 10.1021/jm900752a.
J Med Chem. 2009.
PMID: 19702274
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alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Magnin DR, Biller SA, Chen Y, Dickson JK Jr, Fryszman OM, Lawrence RM, Logan JV, Sieber-McMaster ES, Sulsky RB, Traeger SC, Hsieh DC, Lan SJ, Rinehart JK, Harrity TW, Jolibois KG, Kunselman LK, Rich LC, Slusarchyk DA, Ciosek CP Jr.
Magnin DR, et al. Among authors: sieber mcmaster es.
J Med Chem. 1996 Feb 2;39(3):657-60. doi: 10.1021/jm9507340.
J Med Chem. 1996.
PMID: 8576905
No abstract available.
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Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.
Robl JA, Sulsky R, Sieber-McMaster E, Ryono DE, Cimarusti MP, Simpkins LM, Karanewsky DS, Chao S, Asaad MM, Seymour AA, Fox M, Smith PL, Trippodo NC.
Robl JA, et al. Among authors: sieber mcmaster e.
J Med Chem. 1999 Jan 28;42(2):305-11. doi: 10.1021/jm980542f.
J Med Chem. 1999.
PMID: 9925736
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A pseudopeptide incorporating the tetrahydrophthalazine nucleus, a constrained aza analog of phenylalanine.
Kline T, Mueller L, Sieber-McMaster E, Lau WF, Meyers CA.
Kline T, et al. Among authors: sieber mcmaster e.
Int J Pept Protein Res. 1996 Mar;47(3):142-7. doi: 10.1111/j.1399-3011.1996.tb01337.x.
Int J Pept Protein Res. 1996.
PMID: 8740962
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