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GABAB(1) receptor subunit isoforms differentially regulate stress resilience.
O'Leary OF, Felice D, Galimberti S, Savignac HM, Bravo JA, Crowley T, El Yacoubi M, Vaugeois JM, Gassmann M, Bettler B, Dinan TG, Cryan JF. O'Leary OF, et al. Among authors: bettler b. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15232-7. doi: 10.1073/pnas.1404090111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288769 Free PMC article.
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.
Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC. Revel FG, et al. Among authors: bettler b. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90. doi: 10.1073/pnas.1103029108. Epub 2011 Apr 27. Proc Natl Acad Sci U S A. 2011. PMID: 21525407 Free PMC article.
GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks.
Vertkin I, Styr B, Slomowitz E, Ofir N, Shapira I, Berner D, Fedorova T, Laviv T, Barak-Broner N, Greitzer-Antes D, Gassmann M, Bettler B, Lotan I, Slutsky I. Vertkin I, et al. Among authors: bettler b. Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3291-9. doi: 10.1073/pnas.1424810112. Epub 2015 Jun 8. Proc Natl Acad Sci U S A. 2015. PMID: 26056260 Free PMC article.
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.
Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T. Matsuki T, et al. Among authors: bettler b. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64. doi: 10.1073/pnas.0811126106. Epub 2009 Feb 25. Proc Natl Acad Sci U S A. 2009. PMID: 19246384 Free PMC article.
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.
Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prézeau L. Duthey B, et al. Among authors: bettler b. J Biol Chem. 2002 Feb 1;277(5):3236-41. doi: 10.1074/jbc.M108900200. Epub 2001 Nov 15. J Biol Chem. 2002. PMID: 11711539 Free PMC article.
Although G-protein-coupled receptors (GPCRs) have been shown to assemble into functional homo or heteromers, the role of each protomer in G-protein activation is not known. Among the GPCRs, the gamma-aminobutyric acid (GABA) type B receptor (GABA(B)R) is the only on …
Although G-protein-coupled receptors (GPCRs) have been shown to assemble into functional homo or heteromers, the role of each protomer in G- …
204 results