Freel EM - Search Results

1

Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

Freel EM, Ingram M, Friel EC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe P, Farrall M, Webster J, Clayton D, Dominiczak AF, Davies E, Connell JM. Freel EM, et al. Clin Endocrinol (Oxf). 2007 Dec;67(6):832-8. doi: 10.1111/j.1365-2265.2007.02971.x. Epub 2007 Jul 25. Clin Endocrinol (Oxf). 2007. PMID: 17651452

2

Mechanisms of hypertension: the expanding role of aldosterone.

Freel EM, Connell JM. Freel EM, et al. J Am Soc Nephrol. 2004 Aug;15(8):1993-2001. doi: 10.1097/01.ASN.0000132473.50966.14. J Am Soc Nephrol. 2004. PMID: 15284285 Free PMC article. Review.

3

Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects.

Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM. Freel EM, et al. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. J Clin Endocrinol Metab. 2004. PMID: 15356073 Free PMC article.

4

Diagnosis of adenomatous primary aldosteronism in a patient with severe hypertension.

Freel EM, Connell JM. Freel EM, et al. Nat Clin Pract Endocrinol Metab. 2005 Dec;1(2):111-5; quiz following 115. doi: 10.1038/ncpendmet0047. Nat Clin Pract Endocrinol Metab. 2005. PMID: 16929379

5

A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function.

Connell JM, MacKenzie SM, Freel EM, Fraser R, Davies E. Connell JM, et al. Among authors: freel em. Endocr Rev. 2008 Apr;29(2):133-54. doi: 10.1210/er.2007-0030. Epub 2008 Feb 21. Endocr Rev. 2008. PMID: 18292466 Review.

6

Altered corticosteroid biosynthesis in essential hypertension: A digenic phenomenon.

Davies E, Mackenzie SM, Freel EM, Alvarez-Madrazo S, Fraser R, Connell JM. Davies E, et al. Among authors: freel em. Mol Cell Endocrinol. 2009 Mar 5;300(1-2):185-91. doi: 10.1016/j.mce.2008.09.014. Epub 2008 Sep 19. Mol Cell Endocrinol. 2009. PMID: 18848600 Review.

7

ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.

MacKenzie SM, Freel EM, Connell JM, Fraser R, Davies E. MacKenzie SM, et al. Among authors: freel em. Int J Mol Sci. 2017 Mar 7;18(3):579. doi: 10.3390/ijms18030579. Int J Mol Sci. 2017. PMID: 28272372 Free PMC article. Review.

8

Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy.

Freel EM, Bernhardt R, Ingram M, Wallace AM, Fraser R, Davies E, Connell JM. Freel EM, et al. Clin Endocrinol (Oxf). 2007 May;66(5):659-65. doi: 10.1111/j.1365-2265.2007.02791.x. Epub 2007 Mar 23. Clin Endocrinol (Oxf). 2007. PMID: 17381495

9

Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.

Freel EM, Ingram M, Wallace AM, White A, Fraser R, Davies E, Connell JM. Freel EM, et al. Clin Endocrinol (Oxf). 2008 May;68(5):700-6. doi: 10.1111/j.1365-2265.2007.03116.x. Epub 2007 Nov 2. Clin Endocrinol (Oxf). 2008. PMID: 17980006

10

Plasma steroid profiling and response to trophins to illustrate intra-adrenal dynamics.

McManus F, Fraser R, Davies E, Connell JM, Freel EM. McManus F, et al. Among authors: freel em. J Endocrinol. 2015 Feb;224(2):149-57. doi: 10.1530/JOE-14-0561. Epub 2014 Nov 20. J Endocrinol. 2015. PMID: 25413366 Clinical Trial.

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