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Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.
Freel EM, Ingram M, Friel EC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe P, Farrall M, Webster J, Clayton D, Dominiczak AF, Davies E, Connell JM. Freel EM, et al. Among authors: ingram m. Clin Endocrinol (Oxf). 2007 Dec;67(6):832-8. doi: 10.1111/j.1365-2265.2007.02971.x. Epub 2007 Jul 25. Clin Endocrinol (Oxf). 2007. PMID: 17651452
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.
Keavney B, Mayosi B, Gaukrodger N, Imrie H, Baker M, Fraser R, Ingram M, Watkins H, Farrall M, Davies E, Connell J. Keavney B, et al. Among authors: ingram m. J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. doi: 10.1210/jc.2004-0870. Epub 2004 Nov 2. J Clin Endocrinol Metab. 2005. PMID: 15522937
Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.
Barr M, MacKenzie SM, Friel EC, Holloway CD, Wilkinson DM, Brain NJ, Ingram MC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe PB, Farrall M, Webster J, Clayton D, Dominiczak AF, Connell JM, Davies E. Barr M, et al. Among authors: ingram mc. Hypertension. 2007 Jan;49(1):113-9. doi: 10.1161/01.HYP.0000249904.93940.7a. Epub 2006 Oct 30. Hypertension. 2007. PMID: 17075029
482 results