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Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A. Hikida T, et al. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6. doi: 10.1073/pnas.0704774104. Epub 2007 Aug 3. Proc Natl Acad Sci U S A. 2007. PMID: 17675407 Free PMC article.
Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.
Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A. Jaaro-Peled H, et al. Among authors: hikida t. Neurosci Res. 2016 Nov;112:63-69. doi: 10.1016/j.neures.2016.06.006. Epub 2016 Jun 26. Neurosci Res. 2016. PMID: 27354230 Free PMC article.
Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit.
Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim SH, Zoubovsky S, Hirota-Tsuyada Y, Zala D, Bruyere J, Katz BM, Huang B, Flores R 3rd, Narayan S, Hou Z, Economides AN, Hikida T, Wetsel WC, Deisseroth K, Mori S, Brandon NJ, Tanaka M, Ishizuka K, Houslay MD, Saudou F, Dzirasa K, Sawa A, Tomoda T. Jaaro-Peled H, et al. Among authors: hikida t. Mol Psychiatry. 2022 Mar;27(3):1805-1815. doi: 10.1038/s41380-021-01389-3. Epub 2022 Feb 14. Mol Psychiatry. 2022. PMID: 35165396 Free PMC article.
DISC1 as a therapeutic target for mental illnesses.
Hikida T, Gamo NJ, Sawa A. Hikida T, et al. Expert Opin Ther Targets. 2012 Dec;16(12):1151-60. doi: 10.1517/14728222.2012.719879. Epub 2012 Nov 6. Expert Opin Ther Targets. 2012. PMID: 23130881 Free PMC article. Review.
Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons.
Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T. Sumitomo A, et al. Among authors: hikida t. Hum Mol Genet. 2018 Sep 15;27(18):3165-3176. doi: 10.1093/hmg/ddy219. Hum Mol Genet. 2018. PMID: 29893844 Free PMC article.
Modulation of D-serine levels in brains of mice lacking PICK1.
Hikida T, Mustafa AK, Maeda K, Fujii K, Barrow RK, Saleh M, Huganir RL, Snyder SH, Hashimoto K, Sawa A. Hikida T, et al. Biol Psychiatry. 2008 May 15;63(10):997-1000. doi: 10.1016/j.biopsych.2007.09.025. Epub 2008 Jan 11. Biol Psychiatry. 2008. PMID: 18191108 Free PMC article.
126 results