Worth CL - Search Results

1

Genome bioinformatic analysis of nonsynonymous SNPs.

Burke DF, Worth CL, Priego EM, Cheng T, Smink LJ, Todd JA, Blundell TL. Burke DF, et al. Among authors: worth cl. BMC Bioinformatics. 2007 Aug 20;8:301. doi: 10.1186/1471-2105-8-301. BMC Bioinformatics. 2007. PMID: 17708757 Free PMC article.

2

A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.

Worth CL, Bickerton GR, Schreyer A, Forman JR, Cheng TM, Lee S, Gong S, Burke DF, Blundell TL. Worth CL, et al. J Bioinform Comput Biol. 2007 Dec;5(6):1297-318. doi: 10.1142/s0219720007003120. J Bioinform Comput Biol. 2007. PMID: 18172930

3

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Blundell TL, Sibanda BL, Montalvão RW, Brewerton S, Chelliah V, Worth CL, Harmer NJ, Davies O, Burke D. Blundell TL, et al. Among authors: worth cl. Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):413-23. doi: 10.1098/rstb.2005.1800. Philos Trans R Soc Lond B Biol Sci. 2006. PMID: 16524830 Free PMC article. Review.

4

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.

Forman JR, Worth CL, Bickerton GR, Eisen TG, Blundell TL. Forman JR, et al. Among authors: worth cl. Proteins. 2009 Oct;77(1):84-96. doi: 10.1002/prot.22419. Proteins. 2009. PMID: 19408298

5

Structural and functional constraints in the evolution of protein families.

Worth CL, Gong S, Blundell TL. Worth CL, et al. Nat Rev Mol Cell Biol. 2009 Oct;10(10):709-20. doi: 10.1038/nrm2762. Epub 2009 Sep 16. Nat Rev Mol Cell Biol. 2009. PMID: 19756040 Review.

6

On the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture.

Worth CL, Blundell TL. Worth CL, et al. BMC Evol Biol. 2010 May 31;10:161. doi: 10.1186/1471-2148-10-161. BMC Evol Biol. 2010. PMID: 20513243 Free PMC article.

7

Meet me halfway: when genomics meets structural bioinformatics.

Gong S, Worth CL, Cheng TM, Blundell TL. Gong S, et al. Among authors: worth cl. J Cardiovasc Transl Res. 2011 Jun;4(3):281-303. doi: 10.1007/s12265-011-9259-1. Epub 2011 Feb 25. J Cardiovasc Transl Res. 2011. PMID: 21350909

8

SDM--a server for predicting effects of mutations on protein stability and malfunction.

Worth CL, Preissner R, Blundell TL. Worth CL, et al. Nucleic Acids Res. 2011 Jul;39(Web Server issue):W215-22. doi: 10.1093/nar/gkr363. Epub 2011 May 18. Nucleic Acids Res. 2011. PMID: 21593128 Free PMC article.

9

Structural and functional restraints in the evolution of protein families and superfamilies.

Gong S, Worth CL, Bickerton GR, Lee S, Tanramluk D, Blundell TL. Gong S, et al. Among authors: worth cl. Biochem Soc Trans. 2009 Aug;37(Pt 4):727-33. doi: 10.1042/BST0370727. Biochem Soc Trans. 2009. PMID: 19614584 Review.

10

Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains.

Worth CL, Blundell TL. Worth CL, et al. Proteins. 2009 May 1;75(2):413-29. doi: 10.1002/prot.22248. Proteins. 2009. PMID: 18837037

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