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Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.
Kerr FK, Thomas AR, Wijeyewickrema LC, Whisstock JC, Boyd SE, Kaiserman D, Matthews AY, Bird PI, Thielens NM, Rossi V, Pike RN. Kerr FK, et al. Among authors: kaiserman d. Mol Immunol. 2008 Feb;45(3):670-7. doi: 10.1016/j.molimm.2007.07.008. Epub 2007 Aug 20. Mol Immunol. 2008. PMID: 17709141
Mechanisms of serpin dysfunction in disease.
Kaiserman D, Whisstock JC, Bird PI. Kaiserman D, et al. Expert Rev Mol Med. 2006 Dec 11;8(31):1-19. doi: 10.1017/S1462399406000184. Expert Rev Mol Med. 2006. PMID: 17156576 Review.
The effects of exosite occupancy on the substrate specificity of thrombin.
Ng NM, Quinsey NS, Matthews AY, Kaiserman D, Wijeyewickrema LC, Bird PI, Thompson PE, Pike RN. Ng NM, et al. Among authors: kaiserman d. Arch Biochem Biophys. 2009 Sep;489(1-2):48-54. doi: 10.1016/j.abb.2009.07.012. Epub 2009 Jul 26. Arch Biochem Biophys. 2009. PMID: 19638274
Predicting serpin/protease interactions.
Song J, Matthews AY, Reboul CF, Kaiserman D, Pike RN, Bird PI, Whisstock JC. Song J, et al. Among authors: kaiserman d. Methods Enzymol. 2011;501:237-73. doi: 10.1016/B978-0-12-385950-1.00012-2. Methods Enzymol. 2011. PMID: 22078538
The role of serpins in vertebrate immunity.
Mangan MS, Kaiserman D, Bird PI. Mangan MS, et al. Among authors: kaiserman d. Tissue Antigens. 2008 Jul;72(1):1-10. doi: 10.1111/j.1399-0039.2008.01059.x. Epub 2008 May 20. Tissue Antigens. 2008. PMID: 18498291 Review.
Structure of granzyme C reveals an unusual mechanism of protease autoinhibition.
Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI. Kaiserman D, et al. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5587-92. doi: 10.1073/pnas.0811968106. Epub 2009 Mar 19. Proc Natl Acad Sci U S A. 2009. PMID: 19299505 Free PMC article.
38 results