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Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.
Kerr FK, Thomas AR, Wijeyewickrema LC, Whisstock JC, Boyd SE, Kaiserman D, Matthews AY, Bird PI, Thielens NM, Rossi V, Pike RN. Kerr FK, et al. Among authors: matthews ay. Mol Immunol. 2008 Feb;45(3):670-7. doi: 10.1016/j.molimm.2007.07.008. Epub 2007 Aug 20. Mol Immunol. 2008. PMID: 17709141
Structure of granzyme C reveals an unusual mechanism of protease autoinhibition.
Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI. Kaiserman D, et al. Among authors: matthews ay. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5587-92. doi: 10.1073/pnas.0811968106. Epub 2009 Mar 19. Proc Natl Acad Sci U S A. 2009. PMID: 19299505 Free PMC article.
The effects of exosite occupancy on the substrate specificity of thrombin.
Ng NM, Quinsey NS, Matthews AY, Kaiserman D, Wijeyewickrema LC, Bird PI, Thompson PE, Pike RN. Ng NM, et al. Among authors: matthews ay. Arch Biochem Biophys. 2009 Sep;489(1-2):48-54. doi: 10.1016/j.abb.2009.07.012. Epub 2009 Jul 26. Arch Biochem Biophys. 2009. PMID: 19638274
Predicting serpin/protease interactions.
Song J, Matthews AY, Reboul CF, Kaiserman D, Pike RN, Bird PI, Whisstock JC. Song J, et al. Among authors: matthews ay. Methods Enzymol. 2011;501:237-73. doi: 10.1016/B978-0-12-385950-1.00012-2. Methods Enzymol. 2011. PMID: 22078538
The perforin pore facilitates the delivery of cationic cargos.
Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI. Stewart SE, et al. Among authors: matthews ay. J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20. J Biol Chem. 2014. PMID: 24558045 Free PMC article.
A natural genetic variant of granzyme B confers lethality to a common viral infection.
Andoniou CE, Sutton VR, Wikstrom ME, Fleming P, Thia KY, Matthews AY, Kaiserman D, Schuster IS, Coudert JD, Eldi P, Chaudhri G, Karupiah G, Bird PI, Trapani JA, Degli-Esposti MA. Andoniou CE, et al. Among authors: matthews ay. PLoS Pathog. 2014 Dec 11;10(12):e1004526. doi: 10.1371/journal.ppat.1004526. eCollection 2014 Dec. PLoS Pathog. 2014. PMID: 25502180 Free PMC article.
20 results