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6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.
Issaeva N, Thomas HD, Djureinovic T, Jaspers JE, Stoimenov I, Kyle S, Pedley N, Gottipati P, Zur R, Sleeth K, Chatzakos V, Mulligan EA, Lundin C, Gubanova E, Kersbergen A, Harris AL, Sharma RA, Rottenberg S, Curtin NJ, Helleday T. Issaeva N, et al. Cancer Res. 2010 Aug 1;70(15):6268-76. doi: 10.1158/0008-5472.CAN-09-3416. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631063 Free PMC article.
Repair of abasic sites in DNA.
Dianov GL, Sleeth KM, Dianova II, Allinson SL. Dianov GL, et al. Among authors: sleeth km. Mutat Res. 2003 Oct 29;531(1-2):157-63. doi: 10.1016/j.mrfmmm.2003.09.003. Mutat Res. 2003. PMID: 14637252 Review.
Imaging DNA damage in vivo using gammaH2AX-targeted immunoconjugates.
Cornelissen B, Kersemans V, Darbar S, Thompson J, Shah K, Sleeth K, Hill MA, Vallis KA. Cornelissen B, et al. Cancer Res. 2011 Jul 1;71(13):4539-49. doi: 10.1158/0008-5472.CAN-10-4587. Epub 2011 May 17. Cancer Res. 2011. PMID: 21586614 Free PMC article.