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Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Antimicrob Agents Chemother. 2007 Nov;51(11):3915-23. doi: 10.1128/AAC.00311-07. Epub 2007 Sep 10.
Antimicrob Agents Chemother. 2007.
PMID: 17846131
Free PMC article.
X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).
Eddine AN, von Kries JP, Podust MV, Warrier T, Kaufmann SH, Podust LM.
Eddine AN, et al.
J Biol Chem. 2008 May 30;283(22):15152-9. doi: 10.1074/jbc.M801145200. Epub 2008 Mar 26.
J Biol Chem. 2008.
PMID: 18367444
Free PMC article.
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Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis.
Warrier T, Tropis M, Werngren J, Diehl A, Gengenbacher M, Schlegel B, Schade M, Oschkinat H, Daffe M, Hoffner S, Eddine AN, Kaufmann SH.
Warrier T, et al. Among authors: eddine an.
Antimicrob Agents Chemother. 2012 Apr;56(4):1735-43. doi: 10.1128/AAC.05742-11. Epub 2012 Jan 30.
Antimicrob Agents Chemother. 2012.
PMID: 22290959
Free PMC article.
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Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis.
Janowski R, Panjikar S, Eddine AN, Kaufmann SH, Weiss MS.
Janowski R, et al. Among authors: eddine an.
J Struct Funct Genomics. 2009 Apr;10(2):137-50. doi: 10.1007/s10969-009-9060-4. Epub 2009 Jan 31.
J Struct Funct Genomics. 2009.
PMID: 19184528
Free PMC article.
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A multicistronic DNA vaccine induces significant protection against tuberculosis in mice and offers flexibility in the expressed antigen repertoire.
Mir FA, Kaufmann SH, Eddine AN.
Mir FA, et al. Among authors: eddine an.
Clin Vaccine Immunol. 2009 Oct;16(10):1467-75. doi: 10.1128/CVI.00237-09. Epub 2009 Aug 5.
Clin Vaccine Immunol. 2009.
PMID: 19656992
Free PMC article.
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Reductive methylation to improve crystallization of the putative oxidoreductase Rv0765c from Mycobacterium tuberculosis.
Rauert W, Eddine AN, Kaufmann SH, Weiss MS, Janowski R.
Rauert W, et al. Among authors: eddine an.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):507-11. doi: 10.1107/S1744309107022506. Epub 2007 May 12.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007.
PMID: 17554174
Free PMC article.
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