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Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, Ouellet H, Warrier T, Alteköster M, Lee JS, Rademann J, Oschkinat H, Kaufmann SH, Waterman MR. Podust LM, et al. Among authors: kaufmann sh. Antimicrob Agents Chemother. 2007 Nov;51(11):3915-23. doi: 10.1128/AAC.00311-07. Epub 2007 Sep 10. Antimicrob Agents Chemother. 2007. PMID: 17846131 Free PMC article.
Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis.
Warrier T, Tropis M, Werngren J, Diehl A, Gengenbacher M, Schlegel B, Schade M, Oschkinat H, Daffe M, Hoffner S, Eddine AN, Kaufmann SH. Warrier T, et al. Among authors: kaufmann sh. Antimicrob Agents Chemother. 2012 Apr;56(4):1735-43. doi: 10.1128/AAC.05742-11. Epub 2012 Jan 30. Antimicrob Agents Chemother. 2012. PMID: 22290959 Free PMC article.
AhR sensing of bacterial pigments regulates antibacterial defence.
Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH. Moura-Alves P, et al. Among authors: kaufmann sh. Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13. Nature. 2014. PMID: 25119038
Host monitoring of quorum sensing during Pseudomonas aeruginosa infection.
Moura-Alves P, Puyskens A, Stinn A, Klemm M, Guhlich-Bornhof U, Dorhoi A, Furkert J, Kreuchwig A, Protze J, Lozza L, Pei G, Saikali P, Perdomo C, Mollenkopf HJ, Hurwitz R, Kirschhoefer F, Brenner-Weiss G, Weiner J 3rd, Oschkinat H, Kolbe M, Krause G, Kaufmann SHE. Moura-Alves P, et al. Science. 2019 Dec 20;366(6472):eaaw1629. doi: 10.1126/science.aaw1629. Science. 2019. PMID: 31857448
1,196 results