Waterman MR - Search Results

1

Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.

Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, Ouellet H, Warrier T, Alteköster M, Lee JS, Rademann J, Oschkinat H, Kaufmann SH, Waterman MR. Podust LM, et al. Among authors: waterman mr. Antimicrob Agents Chemother. 2007 Nov;51(11):3915-23. doi: 10.1128/AAC.00311-07. Epub 2007 Sep 10. Antimicrob Agents Chemother. 2007. PMID: 17846131 Free PMC article.

2

Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.

Podust LM, Stojan J, Poulos TL, Waterman MR. Podust LM, et al. Among authors: waterman mr. J Inorg Biochem. 2001 Dec 15;87(4):227-35. doi: 10.1016/s0162-0134(01)00388-9. J Inorg Biochem. 2001. PMID: 11744060

3

Estriol bound and ligand-free structures of sterol 14alpha-demethylase.

Podust LM, Yermalitskaya LV, Lepesheva GI, Podust VN, Dalmasso EA, Waterman MR. Podust LM, et al. Among authors: waterman mr. Structure. 2004 Nov;12(11):1937-45. doi: 10.1016/j.str.2004.08.009. Structure. 2004. PMID: 15530358 Free article.

4

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae.

Sherman DH, Li S, Yermalitskaya LV, Kim Y, Smith JA, Waterman MR, Podust LM. Sherman DH, et al. Among authors: waterman mr. J Biol Chem. 2006 Sep 8;281(36):26289-97. doi: 10.1074/jbc.M605478200. Epub 2006 Jul 6. J Biol Chem. 2006. PMID: 16825192 Free PMC article.

5

The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems.

Podust LM, Kim Y, Arase M, Neely BA, Beck BJ, Bach H, Sherman DH, Lamb DC, Kelly SL, Waterman MR. Podust LM, et al. Among authors: waterman mr. J Biol Chem. 2003 Apr 4;278(14):12214-21. doi: 10.1074/jbc.M212210200. Epub 2003 Jan 7. J Biol Chem. 2003. PMID: 12519772 Free article.

6

Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways.

Podust LM, Bach H, Kim Y, Lamb DC, Arase M, Sherman DH, Kelly SL, Waterman MR. Podust LM, et al. Among authors: waterman mr. Protein Sci. 2004 Jan;13(1):255-68. doi: 10.1110/ps.03384804. Protein Sci. 2004. PMID: 14691240 Free PMC article.

7

Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.

Podust LM, Poulos TL, Waterman MR. Podust LM, et al. Among authors: waterman mr. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3068-73. doi: 10.1073/pnas.061562898. Proc Natl Acad Sci U S A. 2001. PMID: 11248033 Free PMC article.

8

Ligand-assisted inhibition in cytochrome P450 158A2 from Streptomyces coelicolor A3(2).

Zhao B, Waterman MR, Isin EM, Sundaramoorthy M, Podust LM. Zhao B, et al. Among authors: waterman mr. Biochemistry. 2006 Jun 20;45(24):7493-500. doi: 10.1021/bi060193o. Biochemistry. 2006. PMID: 16768445

9

Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs.

Lepesheva GI, Podust LM, Bellamine A, Waterman MR. Lepesheva GI, et al. Among authors: waterman mr. J Biol Chem. 2001 Jul 27;276(30):28413-20. doi: 10.1074/jbc.M102767200. Epub 2001 May 23. J Biol Chem. 2001. PMID: 11373285 Free article.

10

A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.

Lamb DC, Kim Y, Yermalitskaya LV, Yermalitsky VN, Lepesheva GI, Kelly SL, Waterman MR, Podust LM. Lamb DC, et al. Among authors: waterman mr. Structure. 2006 Jan;14(1):51-61. doi: 10.1016/j.str.2005.09.015. Structure. 2006. PMID: 16407065 Free article.

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