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Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Yang H, et al. Among authors: sauve aa. Cell. 2007 Sep 21;130(6):1095-107. doi: 10.1016/j.cell.2007.07.035. Cell. 2007. PMID: 17889652 Free PMC article.
SIRT1 and endocrine signaling.
Yang T, Fu M, Pestell R, Sauve AA. Yang T, et al. Among authors: sauve aa. Trends Endocrinol Metab. 2006 Jul;17(5):186-91. doi: 10.1016/j.tem.2006.04.002. Epub 2006 May 8. Trends Endocrinol Metab. 2006. PMID: 16684606 Review.
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. North BJ, et al. Among authors: sauve aa. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. EMBO J. 2014. PMID: 24825348 Free PMC article.
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.
Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Mitchell SJ, et al. Among authors: sauve aa. Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001. Cell Metab. 2018. PMID: 29514072 Free PMC article.
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C. Tempel W, et al. Among authors: sauve aa. PLoS Biol. 2007 Oct 2;5(10):e263. doi: 10.1371/journal.pbio.0050263. PLoS Biol. 2007. PMID: 17914902 Free PMC article.
70 results