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Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.
Hayden PJ, Tewari P, Morris DW, Staines A, Crowley D, Nieters A, Becker N, de Sanjosé S, Foretova L, Maynadié M, Cocco PL, Boffetta P, Brennan P, Chanock SJ, Browne PV, Lawler M. Hayden PJ, et al. Among authors: browne pv. Hum Mol Genet. 2007 Dec 15;16(24):3117-27. doi: 10.1093/hmg/ddm273. Epub 2007 Sep 26. Hum Mol Genet. 2007. PMID: 17901044
Genetic variation at the 8q24 locus confers risk to multiple myeloma.
Tewari P, Ryan AW, Hayden PJ, Catherwood M, Drain S, Staines A, Grant T, Nieters A, Becker N, de Sanjose S, Foretova L, Maynardie M, Cocco P, Boffetta P, Brennan P, Chanock S, Lawler M, Browne PV. Tewari P, et al. Among authors: browne pv. Br J Haematol. 2012 Jan;156(1):133-6. doi: 10.1111/j.1365-2141.2011.08798.x. Epub 2011 Jul 19. Br J Haematol. 2012. PMID: 21770920 Free article. No abstract available.
PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells.
Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM. Maginn EN, et al. Among authors: browne pv. Br J Cancer. 2011 Jan 18;104(2):281-9. doi: 10.1038/sj.bjc.6606035. Epub 2010 Dec 21. Br J Cancer. 2011. PMID: 21179037 Free PMC article.
Marrow aplasia developing 13 years after HLA-identical sibling allogeneic transplantation for chronic myeloid leukaemia: successful treatment with antithymocyte globulin and peripheral blood stem cell infusion from the original donor.
O'Donghaile D, Hayden PJ, McCarron SL, Doyle EM, Lawler M, Browne PV, Conneally E, Vandenberghe E, McCann SR. O'Donghaile D, et al. Among authors: browne pv. Eur J Haematol. 2006 Mar;76(3):258-60. doi: 10.1111/j.1600-0609.2005.00594.x. Eur J Haematol. 2006. PMID: 16451399
Minimal residual disease detection in childhood acute lymphoblastic leukaemia patients at multiple time-points reveals high levels of concordance between molecular and immunophenotypic approaches.
Ryan J, Quinn F, Meunier A, Boublikova L, Crampe M, Tewari P, O'Marcaigh A, Stallings R, Neat M, O'Meara A, Breatnach F, McCann S, Browne P, Smith O, Lawler M. Ryan J, et al. Br J Haematol. 2009 Jan;144(1):107-15. doi: 10.1111/j.1365-2141.2008.07429.x. Epub 2008 Nov 11. Br J Haematol. 2009. PMID: 19016726 Free article.
A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma.
Amet R, Previtali V, Mihigo HB, Sheridan E, Brophy S, Hante NK, Santos-Martinez MJ, Hayden PJ, Browne PV, Rozas I, McElligott AM, Zisterer DM. Amet R, et al. Among authors: browne pv. Life Sci. 2022 Feb 1;290:120236. doi: 10.1016/j.lfs.2021.120236. Epub 2021 Dec 22. Life Sci. 2022. PMID: 34953891
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