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All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac.
Blood. 2008 Apr 1;111(7):3435-8. doi: 10.1182/blood-2007-08-107086. Epub 2007 Oct 11.
Blood. 2008.
PMID: 17932251
Free PMC article.
Novel methods for determining hematopoietic stem and progenitor cell emergence in the murine yolk sac.
Lux CT, Yoder MC.
Lux CT, et al.
Int J Dev Biol. 2010;54(6-7):1003-9. doi: 10.1387/ijdb.103118cl.
Int J Dev Biol. 2010.
PMID: 20711978
Free PMC article.
Review.
Item in Clipboard
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation.
Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK.
Rhodes KE, et al. Among authors: lux ct.
Cell Stem Cell. 2008 Mar 6;2(3):252-63. doi: 10.1016/j.stem.2008.01.001.
Cell Stem Cell. 2008.
PMID: 18371450
Free PMC article.
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TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.
Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ.
Lux CT, et al.
Mol Ther Methods Clin Dev. 2018 Dec 31;12:175-183. doi: 10.1016/j.omtm.2018.12.008. eCollection 2019 Mar 15.
Mol Ther Methods Clin Dev. 2018.
PMID: 30705922
Free PMC article.
Item in Clipboard
In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods.
Pattabhi S, Lotti SN, Berger MP, Singh S, Lux CT, Jacoby K, Lee C, Negre O, Scharenberg AM, Rawlings DJ.
Pattabhi S, et al. Among authors: lux ct.
Mol Ther Nucleic Acids. 2019 Sep 6;17:277-288. doi: 10.1016/j.omtn.2019.05.025. Epub 2019 Jun 7.
Mol Ther Nucleic Acids. 2019.
PMID: 31279229
Free PMC article.
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Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.
Humbert O, Radtke S, Samuelson C, Carrillo RR, Perez AM, Reddy SS, Lux C, Pattabhi S, Schefter LE, Negre O, Lee CM, Bao G, Adair JE, Peterson CW, Rawlings DJ, Scharenberg AM, Kiem HP.
Humbert O, et al.
Sci Transl Med. 2019 Jul 31;11(503):eaaw3768. doi: 10.1126/scitranslmed.aaw3768.
Sci Transl Med. 2019.
PMID: 31366580
Free PMC article.
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Therapeutic Gene Editing Safety and Specificity.
Lux CT, Scharenberg AM.
Lux CT, et al.
Hematol Oncol Clin North Am. 2017 Oct;31(5):787-795. doi: 10.1016/j.hoc.2017.05.002. Epub 2017 Jun 29.
Hematol Oncol Clin North Am. 2017.
PMID: 28895847
Free PMC article.
Review.
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