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Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.
Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV Jr, Farese RV. Standaert ML, et al. Among authors: sajan mp. J Biol Chem. 2004 Jun 11;279(24):24929-34. doi: 10.1074/jbc.M402440200. Epub 2004 Apr 6. J Biol Chem. 2004. PMID: 15069067 Free article.
Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle.
Frøsig C, Sajan MP, Maarbjerg SJ, Brandt N, Roepstorff C, Wojtaszewski JF, Kiens B, Farese RV, Richter EA. Frøsig C, et al. Among authors: sajan mp. J Physiol. 2007 Aug 1;582(Pt 3):1289-301. doi: 10.1113/jphysiol.2007.136614. Epub 2007 May 31. J Physiol. 2007. PMID: 17540697 Free PMC article.
82 results