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Page 1
In situ proteolysis for protein crystallization and structure determination.
Dong A, Xu X, Edwards AM; Midwest Center for Structural Genomics; Structural Genomics Consortium; Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Gräslund S, Hammerström M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H. Dong A, et al. Among authors: weigelt j. Nat Methods. 2007 Dec;4(12):1019-21. doi: 10.1038/nmeth1118. Epub 2007 Nov 4. Nat Methods. 2007. PMID: 17982461 Free PMC article.
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Vedadi M, Niesen FH, Allali-Hassani A, Fedorov OY, Finerty PJ Jr, Wasney GA, Yeung R, Arrowsmith C, Ball LJ, Berglund H, Hui R, Marsden BD, Nordlund P, Sundstrom M, Weigelt J, Edwards AM. Vedadi M, et al. Among authors: weigelt j. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15835-40. doi: 10.1073/pnas.0605224103. Epub 2006 Oct 11. Proc Natl Acad Sci U S A. 2006. PMID: 17035505 Free PMC article.
Protein production and purification.
Structural Genomics Consortium; China Structural Genomics Consortium; Northeast Structural Genomics Consortium; Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, Park HW, Savchenko A, Yee A, Edwards A, Vincentelli R, Cambillau C, Kim R, Kim SH, Rao Z, Shi Y, Terwilliger TC, Kim CY, Hung LW, Waldo GS, Peleg Y, Albeck S, Unger T, Dym O, Prilusky J, Sussman JL, Stevens RC, Lesley SA, Wilson IA, Joachimiak A, Collart F, Dementieva I, Donnelly MI, Eschenfeldt WH, Kim Y, Stols L, Wu R, Zhou M, Burley SK, Emtage JS, Sauder JM, Thompson D, Bain K, Luz J, Gheyi T, Zhang F, Atwell S, Almo SC, Bonanno JB, Fiser A, Swaminathan S, Studier FW, Chance MR, Sali A, Acton TB, Xiao R, Zhao L, Ma LC, Hunt JF, Tong L, Cunningham K, Inouye M, Anderson S, Janjua H, Shastry R, Ho CK, Wang D, Wang H, Jiang M, Montelione GT, Stuart DI, Owens RJ, Daenke S, Schütz A, Heinemann U, Yokoyama S, Büssow K, Gunsalus KC. Structural Genomics Consortium, et al. Among authors: weigelt j. Nat Methods. 2008 Feb;5(2):135-46. doi: 10.1038/nmeth.f.202. Nat Methods. 2008. PMID: 18235434 Free PMC article. Review.
Structural genomics and drug discovery: all in the family.
Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowsmith CH. Weigelt J, et al. Curr Opin Chem Biol. 2008 Feb;12(1):32-9. doi: 10.1016/j.cbpa.2008.01.045. Epub 2008 Mar 7. Curr Opin Chem Biol. 2008. PMID: 18282486 Review.
The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.
Collins R, Karlberg T, Lehtiö L, Schütz P, van den Berg S, Dahlgren LG, Hammarström M, Weigelt J, Schüler H. Collins R, et al. Among authors: weigelt j. J Biol Chem. 2009 Apr 17;284(16):10296-300. doi: 10.1074/jbc.C900018200. Epub 2009 Feb 25. J Biol Chem. 2009. PMID: 19244245 Free PMC article.
Zinc binding catalytic domain of human tankyrase 1.
Lehtiö L, Collins R, van den Berg S, Johansson A, Dahlgren LG, Hammarström M, Helleday T, Holmberg-Schiavone L, Karlberg T, Weigelt J. Lehtiö L, et al. Among authors: weigelt j. J Mol Biol. 2008 May 23;379(1):136-45. doi: 10.1016/j.jmb.2008.03.058. Epub 2008 Apr 3. J Mol Biol. 2008. PMID: 18436240
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.
Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell AG, Pol E, Frostell Å, Ekblad T, Öncü D, Kull B, Robertson GM, Pellicciari R, Schüler H, Weigelt J. Wahlberg E, et al. Among authors: weigelt j. Nat Biotechnol. 2012 Feb 19;30(3):283-8. doi: 10.1038/nbt.2121. Nat Biotechnol. 2012. PMID: 22343925
228 results