Franklin RB - Search Results

1

Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes.

Zhu B, Bush D, Doss GA, Vincent S, Franklin RB, Xu S. Zhu B, et al. Among authors: franklin rb. Drug Metab Dispos. 2008 Feb;36(2):331-8. doi: 10.1124/dmd.107.017962. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998299

2

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. Huskey SE, et al. Among authors: franklin rb. Drug Metab Dispos. 2004 Feb;32(2):246-58. doi: 10.1124/dmd.32.2.246. Drug Metab Dispos. 2004. PMID: 14744948

3

Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.

Reddy VB, Doss GA, Creighton M, Kochansky CJ, Vincent SH, Franklin RB, Karanam BV. Reddy VB, et al. Among authors: franklin rb. Drug Metab Dispos. 2004 Oct;32(10):1154-61. doi: 10.1124/dmd.104.000240. Epub 2004 Jun 30. Drug Metab Dispos. 2004. PMID: 15229171

4

Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats.

Kim MS, Wang S, Shen Z, Kochansky CJ, Strauss JR, Franklin RB, Vincent SH. Kim MS, et al. Among authors: franklin rb. Drug Metab Dispos. 2004 Sep;32(9):909-14. Drug Metab Dispos. 2004. PMID: 15319330

5

Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.

Kochansky CJ, Xia YQ, Wang S, Cato B, Creighton M, Vincent SH, Franklin RB, Reed JR. Kochansky CJ, et al. Among authors: franklin rb. Drug Metab Dispos. 2005 Dec;33(12):1894-904. doi: 10.1124/dmd.105.004010. Epub 2005 Sep 23. Drug Metab Dispos. 2005. PMID: 16183782

6

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Yin W, Doss GA, Stearns RA, Chaudhary AG, Hop CE, Franklin RB, Kumar S. Yin W, et al. Among authors: franklin rb. Drug Metab Dispos. 2003 Feb;31(2):215-23. doi: 10.1124/dmd.31.2.215. Drug Metab Dispos. 2003. PMID: 12527703

7

Induction of hepatic phase II drug-metabolizing enzymes by 1,7-phenanthroline in rats is accompanied by induction of MRP3.

Wang S, Hartley DP, Ciccotto SL, Vincent SH, Franklin RB, Kim MS. Wang S, et al. Among authors: franklin rb. Drug Metab Dispos. 2003 Jun;31(6):773-5. doi: 10.1124/dmd.31.6.773. Drug Metab Dispos. 2003. PMID: 12756211

8

Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.

Kochansky CJ, Rippley RK, Yan KX, Song H, Wallace MA, Dean D, Jones AN, Lasseter K, Schwartz J, Vincent SH, Franklin RB, Wagner J. Kochansky CJ, et al. Among authors: franklin rb. Drug Metab Dispos. 2006 Sep;34(9):1457-61. doi: 10.1124/dmd.106.010231. Epub 2006 Jun 13. Drug Metab Dispos. 2006. PMID: 16772365 Clinical Trial.

9

The glucuronidation of morphine by dog liver microsomes: identification of morphine-6-O-glucuronide.

King C, Finley B, Franklin R. King C, et al. Drug Metab Dispos. 2000 Jun;28(6):661-3. Drug Metab Dispos. 2000. PMID: 10820138

10

Identification of novel metabolites of pioglitazone in rat and dog.

Shen Z, Reed JR, Creighton M, Liu DQ, Tang YS, Hora DF, Feeney W, Szewczyk J, Bakhtiar R, Franklin RB, Vincent SH. Shen Z, et al. Among authors: franklin rb. Xenobiotica. 2003 May;33(5):499-509. doi: 10.1080/0049825031000085951. Xenobiotica. 2003. PMID: 12746106

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