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Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Kaneko H, et al. Among authors: sisodia ss. J Neurosci. 2007 Nov 28;27(48):13092-7. doi: 10.1523/JNEUROSCI.4244-07.2007. J Neurosci. 2007. PMID: 18045903 Free PMC article.
Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS. Ikeuchi T, et al. Among authors: sisodia ss. J Biol Chem. 2003 Feb 28;278(9):7010-8. doi: 10.1074/jbc.M209252200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12493731 Free article.
Presenilin-1-dependent transcriptome changes.
Mirnics K, Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS. Mirnics K, et al. Among authors: sisodia ss. J Neurosci. 2005 Feb 9;25(6):1571-8. doi: 10.1523/JNEUROSCI.4145-04.2005. J Neurosci. 2005. PMID: 15703411 Free PMC article.
APP processing and synaptic function.
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. Kamenetz F, et al. Neuron. 2003 Mar 27;37(6):925-37. doi: 10.1016/s0896-6273(03)00124-7. Neuron. 2003. PMID: 12670422 Free article.
231 results