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Differences between bisphosphonates in binding affinities for hydroxyapatite.
Lawson MA, Xia Z, Barnett BL, Triffitt JT, Phipps RJ, Dunford JE, Locklin RM, Ebetino FH, Russell RG. Lawson MA, et al. Among authors: barnett bl. J Biomed Mater Res B Appl Biomater. 2010 Jan;92(1):149-55. doi: 10.1002/jbm.b.31500. J Biomed Mater Res B Appl Biomater. 2010. PMID: 19904734
The relationship between the chemistry and biological activity of the bisphosphonates.
Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG. Ebetino FH, et al. Among authors: barnett bl. Bone. 2011 Jul;49(1):20-33. doi: 10.1016/j.bone.2011.03.774. Epub 2011 Apr 9. Bone. 2011. PMID: 21497677 Review.
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Tsoumpra MK, Muniz JR, Barnett BL, Kwaasi AA, Pilka ES, Kavanagh KL, Evdokimov A, Walter RL, Von Delft F, Ebetino FH, Oppermann U, Russell RGG, Dunford JE. Tsoumpra MK, et al. Among authors: barnett bl. Bone. 2015 Dec;81:478-486. doi: 10.1016/j.bone.2015.08.020. Epub 2015 Aug 28. Bone. 2015. PMID: 26318908 Free PMC article.
Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies.
Deprèle S, Kashemirov BA, Hogan JM, Ebetino FH, Barnett BL, Evdokimov A, McKenna CE. Deprèle S, et al. Among authors: barnett bl. Bioorg Med Chem Lett. 2008 May 1;18(9):2878-82. doi: 10.1016/j.bmcl.2008.03.088. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18434151
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Evdokimov AG, Pokross M, Walter RL, Mekel M, Barnett BL, Amburgey J, Seibel WL, Soper SJ, Djung JF, Fairweather N, Diven C, Rastogi V, Grinius L, Klanke C, Siehnel R, Twinem T, Andrews R, Curnow A. Evdokimov AG, et al. Among authors: barnett bl. Proteins. 2007 Feb 15;66(3):538-46. doi: 10.1002/prot.21207. Proteins. 2007. PMID: 17120228
Design and synthesis of conformationally-constrained MMP inhibitors.
Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B. Natchus MG, et al. Among authors: barnett bl. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. doi: 10.1016/s0960-894x(98)00370-9. Bioorg Med Chem Lett. 1998. PMID: 9873489
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