Oppermann U - Search Results

1

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Russell RG, et al. Among authors: oppermann u. Ann N Y Acad Sci. 2007 Nov;1117:209-57. doi: 10.1196/annals.1402.089. Ann N Y Acad Sci. 2007. PMID: 18056045 Review.

2

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U. Kavanagh KL, et al. Among authors: oppermann u. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. doi: 10.1073/pnas.0601643103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684881 Free PMC article.

3

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Dunford JE, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL. Dunford JE, et al. Among authors: oppermann u. J Med Chem. 2008 Apr 10;51(7):2187-95. doi: 10.1021/jm7015733. Epub 2008 Mar 8. J Med Chem. 2008. PMID: 18327899

4

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

Kavanagh KL, Dunford JE, Bunkoczi G, Russell RGG, Oppermann U. Kavanagh KL, et al. Among authors: oppermann u. J Biol Chem. 2006 Aug 4;281(31):22004-22012. doi: 10.1074/jbc.M602603200. Epub 2006 May 11. J Biol Chem. 2006. PMID: 16698791 Free article.

5

The relationship between the chemistry and biological activity of the bisphosphonates.

Ebetino FH, Hogan AM, Sun S, Tsoumpra MK, Duan X, Triffitt JT, Kwaasi AA, Dunford JE, Barnett BL, Oppermann U, Lundy MW, Boyde A, Kashemirov BA, McKenna CE, Russell RG. Ebetino FH, et al. Among authors: oppermann u. Bone. 2011 Jul;49(1):20-33. doi: 10.1016/j.bone.2011.03.774. Epub 2011 Apr 9. Bone. 2011. PMID: 21497677 Review.

6

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Tsoumpra MK, Muniz JR, Barnett BL, Kwaasi AA, Pilka ES, Kavanagh KL, Evdokimov A, Walter RL, Von Delft F, Ebetino FH, Oppermann U, Russell RGG, Dunford JE. Tsoumpra MK, et al. Among authors: oppermann u. Bone. 2015 Dec;81:478-486. doi: 10.1016/j.bone.2015.08.020. Epub 2015 Aug 28. Bone. 2015. PMID: 26318908 Free PMC article.

7

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R. Artz JD, et al. Among authors: oppermann u. Chem Biol. 2008 Dec 22;15(12):1296-306. doi: 10.1016/j.chembiol.2008.10.017. Chem Biol. 2008. PMID: 19101474

8

Structure and function of human 17beta-hydroxysteroid dehydrogenases.

Lukacik P, Kavanagh KL, Oppermann U. Lukacik P, et al. Among authors: oppermann u. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):61-71. doi: 10.1016/j.mce.2005.12.007. Epub 2006 Jan 18. Mol Cell Endocrinol. 2006. PMID: 16414178 Review.

9

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.

Zhang Z, Kochan GT, Ng SS, Kavanagh KL, Oppermann U, Schofield CJ, McDonough MA. Zhang Z, et al. Among authors: oppermann u. Biochem Biophys Res Commun. 2011 May 20;408(4):553-8. doi: 10.1016/j.bbrc.2011.04.059. Epub 2011 Apr 21. Biochem Biophys Res Commun. 2011. PMID: 21530488

10

Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.

Johansson C, Kavanagh KL, Gileadi O, Oppermann U. Johansson C, et al. Among authors: oppermann u. J Biol Chem. 2007 Feb 2;282(5):3077-82. doi: 10.1074/jbc.M608179200. Epub 2006 Nov 22. J Biol Chem. 2007. PMID: 17121859 Free article.

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