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Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.
Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Dubern B, et al. Among authors: clement k. Pediatr Res. 2008 Feb;63(2):211-6. doi: 10.1203/PDR.0b013e31815ed62b. Pediatr Res. 2008. PMID: 18091355
Genetics and the pathophysiology of obesity.
Clément K, Ferré P. Clément K, et al. Pediatr Res. 2003 May;53(5):721-5. doi: 10.1203/01.PDR.0000059753.61905.58. Epub 2003 Mar 5. Pediatr Res. 2003. PMID: 12621112 Review.
Molecular genetics of human obesity-associated MC4R mutations.
Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C. Lubrano-Berthelier C, et al. Among authors: clement k. Ann N Y Acad Sci. 2003 Jun;994:49-57. doi: 10.1111/j.1749-6632.2003.tb03161.x. Ann N Y Acad Sci. 2003. PMID: 12851297 Review.
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clément K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P. Meyre D, et al. Among authors: clement k. Nat Genet. 2005 Aug;37(8):863-7. doi: 10.1038/ng1604. Epub 2005 Jul 17. Nat Genet. 2005. PMID: 16025115 Free PMC article.
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.
Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. Lubrano-Berthelier C, et al. Among authors: clement k. J Clin Endocrinol Metab. 2006 May;91(5):1811-8. doi: 10.1210/jc.2005-1411. Epub 2006 Feb 28. J Clin Endocrinol Metab. 2006. PMID: 16507637
[Genetic aspects of obesity].
Dubern B, Clément K. Dubern B, et al. Among authors: clement k. Presse Med. 2007 Nov;36(11 Pt 2):1598-605. doi: 10.1016/j.lpm.2007.04.013. Epub 2007 May 21. Presse Med. 2007. PMID: 17513079 Review. French.
684 results