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Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma.
Gopal YN, Rizos H, Chen G, Deng W, Frederick DT, Cooper ZA, Scolyer RA, Pupo G, Komurov K, Sehgal V, Zhang J, Patel L, Pereira CG, Broom BM, Mills GB, Ram P, Smith PD, Wargo JA, Long GV, Davies MA. Gopal YN, et al. Cancer Res. 2014 Dec 1;74(23):7037-47. doi: 10.1158/0008-5472.CAN-14-1392. Epub 2014 Oct 8. Cancer Res. 2014. PMID: 25297634 Free PMC article.
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling.
Lu Y, Muller M, Smith D, Dutta B, Komurov K, Iadevaia S, Ruths D, Tseng JT, Yu S, Yu Q, Nakhleh L, Balazsi G, Donnelly J, Schurdak M, Morgan-Lappe S, Fesik S, Ram PT, Mills GB. Lu Y, et al. Among authors: ram pt. Oncogene. 2011 Nov 10;30(45):4567-77. doi: 10.1038/onc.2011.164. Epub 2011 Jun 13. Oncogene. 2011. PMID: 21666717 Free PMC article.
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Hennessy BT, et al. Among authors: ram pt. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. doi: 10.1038/nrd1902. Nat Rev Drug Discov. 2005. PMID: 16341064 Review.
Bioinformatics and systems biology.
Ram PT, Mendelsohn J, Mills GB. Ram PT, et al. Mol Oncol. 2012 Apr;6(2):147-54. doi: 10.1016/j.molonc.2012.01.008. Epub 2012 Feb 17. Mol Oncol. 2012. PMID: 22377422 Free PMC article. Review.
Cancer Systems Biology: a peek into the future of patient care?
Werner HM, Mills GB, Ram PT. Werner HM, et al. Among authors: ram pt. Nat Rev Clin Oncol. 2014 Mar;11(3):167-76. doi: 10.1038/nrclinonc.2014.6. Epub 2014 Feb 4. Nat Rev Clin Oncol. 2014. PMID: 24492837 Free PMC article. Review.
88 results