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SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.
Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. doi: 10.1161/ATVBAHA.107.158030. Epub 2008 Jan 17.
Arterioscler Thromb Vasc Biol. 2008.
PMID: 18202322
Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).
Singh J, Chuaqui CE, Boriack-Sjodin PA, Lee WC, Pontz T, Corbley MJ, Cheung HK, Arduini RM, Mead JN, Newman MN, Papadatos JL, Bowes S, Josiah S, Ling LE.
Singh J, et al. Among authors: mead jn.
Bioorg Med Chem Lett. 2003 Dec 15;13(24):4355-9. doi: 10.1016/j.bmcl.2003.09.028.
Bioorg Med Chem Lett. 2003.
PMID: 14643325
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Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Bridge LJ, Mead J, Frattini E, Winfield I, Ladds G.
Bridge LJ, et al.
J Theor Biol. 2018 Apr 7;442:44-65. doi: 10.1016/j.jtbi.2018.01.010. Epub 2018 Jan 12.
J Theor Biol. 2018.
PMID: 29337260
Free PMC article.
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Engineering a Model Cell for Rational Tuning of GPCR Signaling.
Shaw WM, Yamauchi H, Mead J, Gowers GF, Bell DJ, Öling D, Larsson N, Wigglesworth M, Ladds G, Ellis T.
Shaw WM, et al.
Cell. 2019 Apr 18;177(3):782-796.e27. doi: 10.1016/j.cell.2019.02.023. Epub 2019 Apr 4.
Cell. 2019.
PMID: 30955892
Free PMC article.
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Target cells promote the development and functional maturation of neurons derived from a sympathetic precursor cell line.
Bharmal S, Slonimsky JD, Mead JN, Sampson CP, Tolkovsky AM, Yang B, Bargman R, Birren SJ.
Bharmal S, et al. Among authors: mead jn.
Dev Neurosci. 2001;23(2):153-64. doi: 10.1159/000048707.
Dev Neurosci. 2001.
PMID: 11509838
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Nerve growth factor collaborates with myocyte-derived factors to promote development of presynaptic sites in cultured sympathetic neurons.
Lockhart ST, Mead JN, Pisano JM, Slonimsky JD, Birren SJ.
Lockhart ST, et al. Among authors: mead jn.
J Neurobiol. 2000 Mar;42(4):460-76.
J Neurobiol. 2000.
PMID: 10699983
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