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Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.
Robinson MK, Shaller C, Garmestani K, Plascjak PS, Hodge KM, Yuan QA, Marks JD, Waldmann TA, Brechbiel MW, Adams GP. Robinson MK, et al. Among authors: brechbiel mw. Clin Cancer Res. 2008 Feb 1;14(3):875-82. doi: 10.1158/1078-0432.CCR-07-1250. Clin Cancer Res. 2008. PMID: 18245551 Free PMC article.
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
Yao Z, Zhang M, Axworthy DB, Wong KJ, Garmestani K, Park L, Park CW, Mallett RW, Theodore LJ, Yau EK, Waldmann TA, Brechbiel MW, Paik CH, Pastan I, Carrasquillo JA. Yao Z, et al. Among authors: brechbiel mw. Cancer Res. 2002 Oct 15;62(20):5755-60. Cancer Res. 2002. PMID: 12384535
Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts.
Zhang M, Zhang Z, Garmestani K, Schultz J, Axworthy DB, Goldman CK, Brechbiel MW, Carrasquillo JA, Waldmann TA. Zhang M, et al. Among authors: brechbiel mw. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1891-5. doi: 10.1073/pnas.0437788100. Epub 2003 Feb 4. Proc Natl Acad Sci U S A. 2003. PMID: 12569172 Free PMC article.
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin.
Yao Z, Zhang M, Garmestani K, Axworthy DB, Mallett RW, Fritzberg AR, Theodore LJ, Plascjak PS, Eckelman WC, Waldmann TA, Pastan I, Paik CH, Brechbiel MW, Carrasquillo JA. Yao Z, et al. Among authors: brechbiel mw. Clin Cancer Res. 2004 May 1;10(9):3137-46. doi: 10.1158/1078-0432.ccr-03-0171. Clin Cancer Res. 2004. PMID: 15131055
352 results