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Variations in DNA elucidate molecular networks that cause disease.
Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE. Chen Y, et al. Among authors: zhang b, zhang c. Nature. 2008 Mar 27;452(7186):429-35. doi: 10.1038/nature06757. Epub 2008 Mar 16. Nature. 2008. PMID: 18344982 Free PMC article.
An integrative genomics approach to infer causal associations between gene expression and disease.
Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ. Schadt EE, et al. Among authors: zhang c. Nat Genet. 2005 Jul;37(7):710-7. doi: 10.1038/ng1589. Epub 2005 Jun 19. Nat Genet. 2005. PMID: 15965475 Free PMC article.
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.
Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA. Yang X, et al. Among authors: zhang b, zhang c. Nat Genet. 2009 Apr;41(4):415-23. doi: 10.1038/ng.325. Epub 2009 Mar 8. Nat Genet. 2009. PMID: 19270708 Free PMC article.
Diurnal variation of the human adipose transcriptome and the link to metabolic disease.
Loboda A, Kraft WK, Fine B, Joseph J, Nebozhyn M, Zhang C, He Y, Yang X, Wright C, Morris M, Chalikonda I, Ferguson M, Emilsson V, Leonardson A, Lamb J, Dai H, Schadt E, Greenberg HE, Lum PY. Loboda A, et al. Among authors: zhang c. BMC Med Genomics. 2009 Feb 9;2:7. doi: 10.1186/1755-8794-2-7. BMC Med Genomics. 2009. PMID: 19203388 Free PMC article.
Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting.
Lamb JR, Zhang C, Xie T, Wang K, Zhang B, Hao K, Chudin E, Fraser HB, Millstein J, Ferguson M, Suver C, Ivanovska I, Scott M, Philippar U, Bansal D, Zhang Z, Burchard J, Smith R, Greenawalt D, Cleary M, Derry J, Loboda A, Watters J, Poon RT, Fan ST, Yeung C, Lee NP, Guinney J, Molony C, Emilsson V, Buser-Doepner C, Zhu J, Friend S, Mao M, Shaw PM, Dai H, Luk JM, Schadt EE. Lamb JR, et al. Among authors: zhang b, zhang c, zhang z. PLoS One. 2011;6(7):e20090. doi: 10.1371/journal.pone.0020090. Epub 2011 Jul 5. PLoS One. 2011. PMID: 21750698 Free PMC article.
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. Wang IM, et al. Among authors: zhang b, zhang c. Mol Syst Biol. 2012 Jul 17;8:594. doi: 10.1038/msb.2012.24. Mol Syst Biol. 2012. PMID: 22806142 Free PMC article.
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.
Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V. Zhang B, et al. Among authors: zhang c. Cell. 2013 Apr 25;153(3):707-20. doi: 10.1016/j.cell.2013.03.030. Cell. 2013. PMID: 23622250 Free PMC article.
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