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Mecasermin rinfabate: rhIGF-I/rhIGFBP-3 complex: iPLEX.
Williams RM, McDonald A, O'Savage M, Dunger DB. Williams RM, et al. Expert Opin Drug Metab Toxicol. 2008 Mar;4(3):311-24. doi: 10.1517/17425255.4.3.311. Expert Opin Drug Metab Toxicol. 2008. PMID: 18363546 Review.
Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes.
Saukkonen T, Amin R, Williams RM, Fox C, Yuen KC, White MA, Umpleby AM, Acerini CL, Dunger DB. Saukkonen T, et al. Among authors: williams rm. J Clin Endocrinol Metab. 2004 Sep;89(9):4634-41. doi: 10.1210/jc.2004-0243. J Clin Endocrinol Metab. 2004. PMID: 15356074 Clinical Trial.
IGF-I treatment of insulin resistance.
McDonald A, Williams RM, Regan FM, Semple RK, Dunger DB. McDonald A, et al. Among authors: williams rm. Eur J Endocrinol. 2007 Aug;157 Suppl 1:S51-6. doi: 10.1530/EJE-07-0271. Eur J Endocrinol. 2007. PMID: 17785698 Review.
Treatment with recombinant human insulin-like growth factor (rhIGF)-I/rhIGF binding protein-3 complex improves metabolic control in subjects with severe insulin resistance.
Regan FM, Williams RM, McDonald A, Umpleby AM, Acerini CL, O'Rahilly S, Hovorka R, Semple RK, Dunger DB. Regan FM, et al. Among authors: williams rm. J Clin Endocrinol Metab. 2010 May;95(5):2113-22. doi: 10.1210/jc.2009-2088. Epub 2010 Mar 16. J Clin Endocrinol Metab. 2010. PMID: 20233784
A family with severe insulin resistance and diabetes due to a mutation in AKT2.
George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, O'Rahilly S, Barroso I. George S, et al. Among authors: williams rm. Science. 2004 May 28;304(5675):1325-8. doi: 10.1126/science.1096706. Science. 2004. PMID: 15166380 Free PMC article.
Increasing urine albumin excretion is associated with growth hormone hypersecretion and reduced clearance of insulin in adolescents and young adults with type 1 diabetes: the Oxford Regional Prospective Study.
Amin R, Williams RM, Frystyk J, Umpleby M, Matthews D, Orskov H, Dalton RN, Dunger DB. Amin R, et al. Among authors: williams rm. Clin Endocrinol (Oxf). 2005 Feb;62(2):137-44. doi: 10.1111/j.1365-2265.2005.02185.x. Clin Endocrinol (Oxf). 2005. PMID: 15670188
Short-term suppression of elevated growth hormone concentrations following insulin-like growth factor 1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates.
Williams RM, Yuen K, White D, Mallard B, Dalton RN, Acerini CL, Dunger DB. Williams RM, et al. Clin Endocrinol (Oxf). 2006 Oct;65(4):439-45. doi: 10.1111/j.1365-2265.2006.02600.x. Clin Endocrinol (Oxf). 2006. PMID: 16984235 Clinical Trial.
814 results