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Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion.
Jacobson PB, Mothe A, Levy A, Krakovsky M, Hooker BA, Zhang X, Mollon J, Mordashova Y, Droescher M, Weiss S, Barghorn S, Dreher I, Awwad K, Nimmrich V, Huang L, Fung E, Buck WR, Pfleeger K, Ziemann A, Smith E, Fox GB, Tator CH, Gold M. Jacobson PB, et al. Transl Stroke Res. 2023 Jun 16. doi: 10.1007/s12975-023-01164-2. Online ahead of print. Transl Stroke Res. 2023. PMID: 37326791
Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.
Wakeman DR, Weed MR, Perez SE, Cline EN, Viola KL, Wilcox KC, Moddrelle DS, Nisbett EZ, Kurian AM, Bell AF, Pike R, Jacobson PB, Klein WL, Mufson EJ, Lawrence MS, Elsworth JD. Wakeman DR, et al. Among authors: jacobson pb. Neuropathol Appl Neurobiol. 2022 Jun;48(4):e12800. doi: 10.1111/nan.12800. Epub 2022 Mar 2. Neuropathol Appl Neurobiol. 2022. PMID: 35156715 Free PMC article.
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Jacobson PB, Goody R, Lawrence M, Mueller BK, Zhang X, Hooker BA, Pfleeger K, Ziemann A, Locke C, Barraud Q, Droescher M, Bernhard J, Popp A, Boeser P, Huang L, Mollon J, Mordashova Y, Cui YF, Savaryn JP, Grinnell C, Dreher I, Gold M, Courtine G, Mothe A, Tator CH, Guest JD. Jacobson PB, et al. Neurobiol Dis. 2021 Jul;155:105385. doi: 10.1016/j.nbd.2021.105385. Epub 2021 May 12. Neurobiol Dis. 2021. PMID: 33991647 Free article.
Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
Zhu CZ, Chin CL, Rustay NR, Zhong C, Mikusa J, Chandran P, Salyers A, Gomez E, Simler G, Lewis LG, Gauvin D, Baker S, Pai M, Tovcimak A, Brown J, Komater V, Fox GB, Decker MW, Jacobson PB, Gopalakrishnan M, Lee CH, Honore P. Zhu CZ, et al. Among authors: jacobson pb. Biochem Pharmacol. 2011 Oct 15;82(8):967-76. doi: 10.1016/j.bcp.2011.05.007. Epub 2011 May 17. Biochem Pharmacol. 2011. PMID: 21620806
Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis.
Mayer AM, Guzman M, Peksa R, Hall M, Fay MJ, Jacobson PB, Romanic AM, Gunasekera SP. Mayer AM, et al. Among authors: jacobson pb. Mar Drugs. 2007;5(3):113-35. doi: 10.3390/md503113. Mar Drugs. 2007. PMID: 18458762 Free PMC article.
43 results