Garcia ML - Search Results

1

Miniaturization and HTS of a FRET-based membrane potential assay for K(ir) channel inhibitors.

Solly K, Cassaday J, Felix JP, Garcia ML, Ferrer M, Strulovici B, Kiss L. Solly K, et al. Among authors: garcia ml. Assay Drug Dev Technol. 2008 Apr;6(2):225-34. doi: 10.1089/adt.2008.123. Assay Drug Dev Technol. 2008. PMID: 18471076

2

Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

Felix JP, Williams BS, Priest BT, Brochu RM, Dick IE, Warren VA, Yan L, Slaughter RS, Kaczorowski GJ, Smith MM, Garcia ML. Felix JP, et al. Among authors: garcia ml. Assay Drug Dev Technol. 2004 Jun;2(3):260-8. doi: 10.1089/1540658041410696. Assay Drug Dev Technol. 2004. PMID: 15285907

3

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

Liu CJ, Priest BT, Bugianesi RM, Dulski PM, Felix JP, Dick IE, Brochu RM, Knaus HG, Middleton RE, Kaczorowski GJ, Slaughter RS, Garcia ML, Köhler MG. Liu CJ, et al. Among authors: garcia ml. Assay Drug Dev Technol. 2006 Feb;4(1):37-48. doi: 10.1089/adt.2006.4.37. Assay Drug Dev Technol. 2006. PMID: 16506887

4

A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.

Schmalhofer WA, Swensen AM, Thomas BS, Felix JP, Haedo RJ, Solly K, Kiss L, Kaczorowski GJ, Garcia ML. Schmalhofer WA, et al. Among authors: garcia ml. Assay Drug Dev Technol. 2010 Dec;8(6):714-26. doi: 10.1089/adt.2010.0351. Assay Drug Dev Technol. 2010. PMID: 21158686

5

The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.

Felix JP, Priest BT, Solly K, Bailey T, Brochu RM, Liu CJ, Kohler MG, Kiss L, Alonso-Galicia M, Tang H, Pasternak A, Kaczorowski GJ, Garcia ML. Felix JP, et al. Among authors: garcia ml. Assay Drug Dev Technol. 2012 Oct;10(5):417-31. doi: 10.1089/adt.2012.462. Epub 2012 Aug 10. Assay Drug Dev Technol. 2012. PMID: 22881347

6

A high-capacity membrane potential FRET-based assay for the sodium-coupled glucose co-transporter SGLT1.

Weinglass AB, Swensen AM, Liu J, Schmalhofer W, Thomas A, Williams B, Ross L, Hashizume K, Kohler M, Kaczorowski GJ, Garcia ML. Weinglass AB, et al. Among authors: garcia ml. Assay Drug Dev Technol. 2008 Apr;6(2):255-62. doi: 10.1089/adt.2008.125. Assay Drug Dev Technol. 2008. PMID: 18471079

7

Identification of novel and selective Kv2 channel inhibitors.

Herrington J, Solly K, Ratliff KS, Li N, Zhou YP, Howard A, Kiss L, Garcia ML, McManus OB, Deng Q, Desai R, Xiong Y, Kaczorowski GJ. Herrington J, et al. Among authors: garcia ml. Mol Pharmacol. 2011 Dec;80(6):959-64. doi: 10.1124/mol.111.074831. Epub 2011 Sep 26. Mol Pharmacol. 2011. PMID: 21948463

8

Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.

Felix JP, Liu J, Schmalhofer WA, Bailey T, Bednarek MA, Kinkel S, Weinglass AB, Kohler M, Kaczorowski GJ, Priest BT, Garcia ML. Felix JP, et al. Among authors: garcia ml. Biochemistry. 2006 Aug 22;45(33):10129-39. doi: 10.1021/bi060509s. Biochemistry. 2006. PMID: 16906771

9

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

Williams BS, Felix JP, Priest BT, Brochu RM, Dai K, Hoyt SB, London C, Tang YS, Duffy JL, Parsons WH, Kaczorowski GJ, Garcia ML. Williams BS, et al. Among authors: garcia ml. Biochemistry. 2007 Dec 18;46(50):14693-703. doi: 10.1021/bi7018207. Epub 2007 Nov 21. Biochemistry. 2007. PMID: 18027973

10

3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.

Hoyt SB, London C, Wyvratt MJ, Fisher MH, Cashen DE, Felix JP, Garcia ML, Li X, Lyons KA, Euan MacIntyre D, Martin WJ, Priest BT, Smith MM, Warren VA, Williams BS, Kaczorowski GJ, Parsons WH. Hoyt SB, et al. Among authors: garcia ml. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1963-6. doi: 10.1016/j.bmcl.2008.01.123. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18289851

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